AIDP, Acute inflammatory demyelinating polyradiculoneuropathy entities

Acquired acute demyelinating peripheral polyneuropathy (AADP) is a general classification of pathologies that could affect secondary the peripheral nervous system. They are characterized by an autoimmune inflammation of myelin and Clinically characterized by progressive weakness and mild sensory changes.

Acute inflammatory demyelinating polyneuropathy (AIDP) often is referred to as Guillain-Barré syndrome (GBS). GBS is an autoimmune Poly neuropathy in response to viral agents (INFL, CXA , CXB, EBV, or CMV) or bacterial organisms (Campylobacter jejuni, Mycoplasma pneumoniae). It is a progressive usually bilateral weakness, hyporeflexia, with a typical demyelinating EMG pattern. Progressive affection of respiratory muscles and autonomic instability may leads to mortality.

AIDP has a typical GBS presentation but with a unilateral upgoing plantar reflex (Babinski sign/Plantar reflex). A unifying diagnosis was made and based on a literature search in Pubmed appears to be the first described case of its kind.

Note

Babinski sign = Increased Plantar reflex = Hyper reflexia is the sign of Upper motor neuron lesion

Miasm

GSS: Paralysis + Hyper reflexia + Incoordination