Autoimmune basal ganglia encephalitis: Difference between revisions
Jump to navigation
Jump to search
m (1 revision imported) |
|||
| Line 24: | Line 24: | ||
=== Causation<ref>G. C. Beattie, C. A. Glaser, H. Sheriff, S. Messenger, C. P. Preas, M. Shahkarami, A. Venkatesan, Encephalitis With Thalamic and Basal Ganglia Abnormalities: Etiologies, Neuroimaging, and Potential Role of Respiratory Viruses, ''Clinical Infectious Diseases'', Volume 56, Issue 6, 15 March 2013, Pages 825–832, <nowiki>https://doi.org/10.1093/cid/cis990</nowiki></ref> | === Causation === | ||
Reference <ref>G. C. Beattie, C. A. Glaser, H. Sheriff, S. Messenger, C. P. Preas, M. Shahkarami, A. Venkatesan, Encephalitis With Thalamic and Basal Ganglia Abnormalities: Etiologies, Neuroimaging, and Potential Role of Respiratory Viruses, ''Clinical Infectious Diseases'', Volume 56, Issue 6, 15 March 2013, Pages 825–832, <nowiki>https://doi.org/10.1093/cid/cis990</nowiki></ref> | |||
* Respiratory viruses (INFL, RSV, PIV , HMPV, RNV, COV-2, COV-19, ADV, [[HBOV, Human Boca Virus|HBOV]]) | * Respiratory viruses (INFL, RSV, PIV , HMPV, RNV, COV-2, COV-19, ADV, [[HBOV, Human Boca Virus|HBOV]]) | ||
* CJD | * CJD | ||
Latest revision as of 06:55, 3 April 2023
Clinic
- BGE is characterized by the relatively rapid development of symptoms of parkinsonism such as akinesia, rigidity, and tremors.
- Autoimmune inflammation of the basal ganglia structures.
- Various autoantibodies, namely, dopamine D2 receptor (D2R), N-methyl-D-aspartate receptor (NMDAR), and anti-LGI1, trigger it.
- When it occurs as a paraneoplastic manifestation usually due to ovarian teratomas, then anti-recoverin antibodies are classically associated. In these cases, there is additional development of retinopathy, also termed cancer-associated retinopathy (CAR)
- The clinical presentation can also include other features such as
- Cognitive abnormalities
- Seizures
PANDAS
PANS and PANDAS are a type of basal ganglia encephalitis.
- Obsessions/compulsions
- Depression
- Mood swings
- Acute movement disorders
- Executive dysfunction
- Fine motor difficulties
- Anxiety [1]
Causation
Reference [2]
- Respiratory viruses (INFL, RSV, PIV , HMPV, RNV, COV-2, COV-19, ADV, HBOV)
- CJD
- Arbovirus (DHF, RVF, JE, WNE, TBE, YF)
- MTB
Entities / Miasms
| CJD | JE | WNE | TBE | |
|---|---|---|---|---|
| Parkinsonism
(Rigidity / Bradikinesia / Tremor) |
3+ | 3+ | 3+ | 1+ |
| Cognition impaired (executive function) | 2+ | 3+ | 2+ | 3+ |
| Emotional lability / Anxiety / Depression | -- | 1+ | -- | 3+ |
| Awakward, Inccordination | 1+ | 3+ | 2+ | 3+ |
| Seizure | 2+ | 3+ | -- | 2+ |
- ↑ Pawela C, Brunsdon RK, Williams TA, Porter M, Dale RC, Mohammad SS. The neuropsychological profile of children with basal ganglia encephalitis: a case series. Dev Med Child Neurol. 2017 Apr;59(4):445-448. doi: 10.1111/dmcn.13351. Epub 2016 Dec 19. PMID: 27991656.
- ↑ G. C. Beattie, C. A. Glaser, H. Sheriff, S. Messenger, C. P. Preas, M. Shahkarami, A. Venkatesan, Encephalitis With Thalamic and Basal Ganglia Abnormalities: Etiologies, Neuroimaging, and Potential Role of Respiratory Viruses, Clinical Infectious Diseases, Volume 56, Issue 6, 15 March 2013, Pages 825–832, https://doi.org/10.1093/cid/cis990