Erythema multiforme: Difference between revisions

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(Created page with "=== Clinic === * EM is a skin condition that appears with red patches evolving into target lesions, typically on both hands. * It is a type of erythema possibly mediated by deposition of immune complexes (mostly IgM-bound complexes) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure. * The condition varies from a mild, self-limited rash to a severe, life-threatening form known as '''erythema multi...")
 
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* EM is a skin condition that appears with red patches evolving into target lesions, typically on both hands.
* EM is a skin condition that appears with red patches evolving into target lesions, typically on both hands.


* It is a type of erythema possibly mediated by deposition of immune complexes (mostly IgM-bound complexes) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure.
* It is a type of erythema possibly mediated by deposition of immune complexes in the superficial microvasculature of the skin and oral mucous membrane
* The condition varies from a mild, self-limited rash to a severe, life-threatening form known as '''erythema multiforme major''' that also involves mucous membranes. Consensus classification:


=== Causes ===
=== Causes ===
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* Bacterial ( Bacillus Calmette–Guérin (BCG) vaccination, haemolytic ''Streptococci'', legionellosis, leprosy, ''Neisseria meningitidis'', ''Mycobacterium'', ''Pneumococcus'', ''Salmonella'' species, ''Staphylococcus'' species, ''Mycoplasma pneumoniae(More common''), chlamydial.
* Bacterial ( Bacillus Calmette–Guérin (BCG) vaccination, haemolytic ''Streptococci'', legionellosis, leprosy, ''Neisseria meningitidis'', ''Mycobacterium'', ''Pneumococcus'', ''Salmonella'' species, ''Staphylococcus'' species, ''Mycoplasma pneumoniae(More common''), chlamydial.
* Fungal (Coccidioides immitis)
* Fungal (Coccidioides immitis)
* Parasitic (''Trichomonas'' species, ''Toxoplasma gondii),''
* Parasitic (''Trichomonas'' species, ''[[TPG, Toxoplasma gondii|Toxoplasma gondii]])''
* Viral (esp HSV-1, HSV-2) (55% of cases)
* Viral ([[HSV-1, Herpes Simplex Virus|HSV-1]], [[HSV-2, Herpes Simplex Virus|HSV-2]] in 55% of cases)
* Drug reactions,
* Drug reactions
* Physical factors: radiotherapy, cold, sunlight
* Physical factors: radiotherapy, cold, sunlight
* Others: collagen diseases, vasculitides, non-Hodgkin lymphoma, leukaemia, multiple myeloma, myeloid metaplasia, polycythemia


 
=== Related Diseases ===
=== Related disease ===
* Collagen diseases
* Vasculitides
* Non-Hodgkin lymphoma
* Leukaemia
* [[Multiple myeloma]]
* Myeloid metaplasia
* Polycythemia


* Stevens–Johnson syndrome
* Stevens–Johnson syndrome

Latest revision as of 23:13, 23 September 2023

Clinic

  • EM is a skin condition that appears with red patches evolving into target lesions, typically on both hands.
  • It is a type of erythema possibly mediated by deposition of immune complexes in the superficial microvasculature of the skin and oral mucous membrane

Causes

  • Bacterial ( Bacillus Calmette–Guérin (BCG) vaccination, haemolytic Streptococci, legionellosis, leprosy, Neisseria meningitidis, Mycobacterium, Pneumococcus, Salmonella species, Staphylococcus species, Mycoplasma pneumoniae(More common), chlamydial.
  • Fungal (Coccidioides immitis)
  • Parasitic (Trichomonas species, Toxoplasma gondii)
  • Viral (HSV-1, HSV-2 in 55% of cases)
  • Drug reactions
  • Physical factors: radiotherapy, cold, sunlight

Related Diseases

  • Collagen diseases
  • Vasculitides
  • Non-Hodgkin lymphoma
  • Leukaemia
  • Multiple myeloma
  • Myeloid metaplasia
  • Polycythemia
  • Stevens–Johnson syndrome
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