Pure Autonomic Failure: Difference between revisions

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* PAF is a neurodegenerative disorder of the [[Autonomic Nervous System|autonomic nervous system]] clinically characterized by [[Syncope|orthostatic hypotension]].  
* PAF is a neurodegenerative disorder of the [[Autonomic Nervous System|autonomic nervous system]] clinically characterized by [[Syncope|orthostatic hypotension]].  
* It has also been known as Bradbury-Eggleston syndrome
* It has also been known as Bradbury-Eggleston syndrome
* Patients typically present in midlife or later with orthostatic hypotension or syncope.
* Autonomic failure may also manifest as genitourinary, bowel, and [[Thermoregulatory disorder|thermoregulatory dysfunction]].  
* Autonomic failure may also manifest as genitourinary, bowel, and thermoregulatory dysfunction. With widespread involvement, patients may present to a variety of different specialties and require multidisciplinary treatment approaches.  
* Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein.  
* Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein.  
* PAF may progress into other synucleinopathies with CNS involvement <ref>https://www.mayoclinicproceedings.org/article/S0025-6196(19)30265-4/fulltext#:~:text=Pure%20autonomic%20failure%20(PAF)%20is,of%20the%201925%20seminal%20description.</ref>
* PAF may progress into other synucleinopathies with CNS involvement <ref>https://www.mayoclinicproceedings.org/article/S0025-6196(19)30265-4/fulltext#:~:text=Pure%20autonomic%20failure%20(PAF)%20is,of%20the%201925%20seminal%20description.</ref>


=== Miasm ===
=== Miasm ===
Same as Neurogenic Syncope
Same as Neurogenic [[Syncope]]

Latest revision as of 23:54, 2 October 2023

Clinic

  • PAF is a neurodegenerative disorder of the autonomic nervous system clinically characterized by orthostatic hypotension.
  • It has also been known as Bradbury-Eggleston syndrome
  • Autonomic failure may also manifest as genitourinary, bowel, and thermoregulatory dysfunction.
  • Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein.
  • PAF may progress into other synucleinopathies with CNS involvement [1]

Miasm

Same as Neurogenic Syncope

  1. ↑ https://www.mayoclinicproceedings.org/article/S0025-6196(19)30265-4/fulltext#:~:text=Pure%20autonomic%20failure%20(PAF)%20is,of%20the%201925%20seminal%20description.
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