Protein losing enteropathy: Difference between revisions
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* PLE is a kind of [[Enteropathy]], refers to any condition of the GI tract that results in a net loss of protein from the body. | * PLE is a kind of [[Enteropathy]], refers to any condition of the GI tract that results in a net loss of protein from the body. | ||
* Signs/ | * Signs/ Symptoms are [[Diarrhea]], Fever, and Abdominal discomfort. | ||
* Swelling of the legs due to peripheral edema | * Swelling of the legs due to peripheral edema | ||
* | * PLE is related to a systemic disease such as [[Heart Failure|congestive heart failure]] or constrictive [[pericarditis]]. | ||
=== Causes === | === Causes === | ||
{| class="wikitable" | |||
* [[IBD, Inflammatory bowel disease|IBD]] (Crohn’s disease) | |+ | ||
! | |||
! | |||
* [[MTB, Mycobacterium tuberculosis|MTB]]: | |- | ||
| | |||
* [[Amyloidosis]] | |||
* [[Celiac disease|Coeliac disease]] | |||
* [[Eosinophilic Gastroenteritis or Enteropathy|Eosinophilic gastroenteritis]] | |||
* [[IBD, Inflammatory bowel disease|IBD]] ([[Crohn's disease|Crohn’s disease]]) | |||
* [[MTB, Mycobacterium tuberculosis|MTB]]: PLE in Association With Tuberculosis-Related Constrictive Pericarditis. <ref>Front. Pediatr., 30 May 2022 | |||
Sec. Pediatric Gastroenterology, Hepatology and Nutrition | Sec. Pediatric Gastroenterology, Hepatology and Nutrition | ||
Volume 10 - 2022 | <nowiki>https://doi.org/10.3389/fped.2022.875032</nowiki></ref> | Volume 10 - 2022 | <nowiki>https://doi.org/10.3389/fped.2022.875032</nowiki></ref> | ||
* [[Sarcoidosis]] (Secondary obstruction). | |||
* [[Sarcoidosis]] ( | |||
* [[SLE, Systemic lupus erythematosus|SLE]] | * [[SLE, Systemic lupus erythematosus|SLE]] | ||
| | |||
*Congenital heart defect (single ventricle following surgical repair resulting in congestive heart failure) | |||
* Idiopathic ulcerative jejunoileitis | |||
* Neoplasm (Secondary obstruction) | |||
* Ménétrier's disease | * Ménétrier's disease | ||
* Zollinger-Ellison syndrome | * Zollinger-Ellison syndrome | ||
* Common variable immunodeficiency (CVID) | * Common variable immunodeficiency (CVID) | ||
* Primary intestinal lymphangectasia | * Primary intestinal lymphangectasia | ||
|} | |||
=== Types === | === Types === | ||
PLE in relation to the associated pathology for three different disease categories: <ref>Levitt DG, Levitt MD. Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states. Clin Exp Gastroenterol. 2017 Jul 17;10:147-168. doi: 10.2147/CEG.S136803. PMID: 28761367; PMCID: PMC5522668.</ref> | PLE in relation to the associated pathology for three different disease categories: <ref>Levitt DG, Levitt MD. Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states. Clin Exp Gastroenterol. 2017 Jul 17;10:147-168. doi: 10.2147/CEG.S136803. PMID: 28761367; PMCID: PMC5522668.</ref> | ||
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=== Note === | === Note === | ||
We could consider [[MTB, Mycobacterium tuberculosis|MTB]] and [[CMV, Cytomegalovirus|CMV]] as a good candidate miasm for IBD and Celiac | We could consider [[MTB, Mycobacterium tuberculosis|MTB]] and [[CMV, Cytomegalovirus|CMV]] as a good candidate miasm for [[IBD, Inflammatory bowel disease|IBD]] and [[Celiac disease]] | ||
<references /> | <references /> |
Latest revision as of 00:32, 8 December 2023
Clinic
- PLE is a kind of Enteropathy, refers to any condition of the GI tract that results in a net loss of protein from the body.
- Signs/ Symptoms are Diarrhea, Fever, and Abdominal discomfort.
- Swelling of the legs due to peripheral edema
- PLE is related to a systemic disease such as congestive heart failure or constrictive pericarditis.
Causes
|
|
Types
PLE in relation to the associated pathology for three different disease categories: [2]
- Increased lymphatic pressure (e.g., lymphangiectasis)
- Diseases with mucosal erosions (e.g., Crohn’s disease)
- Diseases without mucosal erosions (e.g., Celiac disease)
Note
We could consider MTB and CMV as a good candidate miasm for IBD and Celiac disease
- ↑ Front. Pediatr., 30 May 2022 Sec. Pediatric Gastroenterology, Hepatology and Nutrition Volume 10 - 2022 | https://doi.org/10.3389/fped.2022.875032
- ↑ Levitt DG, Levitt MD. Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states. Clin Exp Gastroenterol. 2017 Jul 17;10:147-168. doi: 10.2147/CEG.S136803. PMID: 28761367; PMCID: PMC5522668.