Protein losing enteropathy: Difference between revisions

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* PLE is a kind of [[Enteropathy]], refers to any condition of the GI tract  that results in a net loss of protein from the body.
* PLE is a kind of [[Enteropathy]], refers to any condition of the GI tract  that results in a net loss of protein from the body.
* Signs/symptoms are Diarrhea, Fever, and General abdominal discomfort.  
* Signs/ Symptoms are [[Diarrhea]], Fever, and Abdominal discomfort.  
* Swelling of the legs due to peripheral edema can also occur, however,
* Swelling of the legs due to peripheral edema
* If PLE is related to a systemic disease such as congestive heart failure or constrictive pericarditis, then the symptoms could be of the primary disease development.
* PLE is related to a systemic disease such as [[Heart Failure|congestive heart failure]] or constrictive [[pericarditis]].






=== Causes ===
=== Causes ===
 
{| class="wikitable"
* [[IBD, Inflammatory bowel disease|IBD]] (Crohn’s disease)
|+
* Congenital heart defect (single ventricle following surgical repair resulting in congestive heart failure)
!
* Idiopathic ulcerative jejunoileitis
!
* [[MTB, Mycobacterium tuberculosis|MTB]]: Protein-Losing Enteropathy in Association With Tuberculosis-Related Constrictive Pericarditis. <ref>Front. Pediatr., 30 May 2022
|-
|
* [[Amyloidosis]]
* [[Celiac disease|Coeliac disease]]
* [[Eosinophilic Gastroenteritis or Enteropathy|Eosinophilic gastroenteritis]]
* [[IBD, Inflammatory bowel disease|IBD]] ([[Crohn's disease|Crohn’s disease]])
* [[MTB, Mycobacterium tuberculosis|MTB]]: PLE in Association With Tuberculosis-Related Constrictive Pericarditis. <ref>Front. Pediatr., 30 May 2022


Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Sec. Pediatric Gastroenterology, Hepatology and Nutrition


Volume 10 - 2022 | <nowiki>https://doi.org/10.3389/fped.2022.875032</nowiki></ref>
Volume 10 - 2022 | <nowiki>https://doi.org/10.3389/fped.2022.875032</nowiki></ref>
* Neoplasm (secondary obstruction)
* [[Sarcoidosis]] (Secondary obstruction).
* [[Sarcoidosis]] (secondary obstruction).
* Amyloidosis
* [[SLE, Systemic lupus erythematosus|SLE]]
* [[SLE, Systemic lupus erythematosus|SLE]]
|
*Congenital heart defect (single ventricle following surgical repair resulting in congestive heart failure)
* Idiopathic ulcerative jejunoileitis
* Neoplasm (Secondary obstruction)
* Ménétrier's disease
* Ménétrier's disease
* Zollinger-Ellison syndrome
* Zollinger-Ellison syndrome
* [[Eosinophilic Gastroenteritis or Enteropathy|Eosinophilic gastroenteritis]]
* [[Celiac disease|Coeliac disease]]
* Common variable immunodeficiency (CVID)
* Common variable immunodeficiency (CVID)
* Primary intestinal lymphangectasia
* Primary intestinal lymphangectasia
|}


=== Types ===
=== Types ===


PLE in relation to the associated pathology for three different disease categories: <ref>Levitt DG, Levitt MD. Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states. Clin Exp Gastroenterol. 2017 Jul 17;10:147-168. doi: 10.2147/CEG.S136803. PMID: 28761367; PMCID: PMC5522668.</ref>
PLE in relation to the associated pathology for three different disease categories: <ref>Levitt DG, Levitt MD. Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states. Clin Exp Gastroenterol. 2017 Jul 17;10:147-168. doi: 10.2147/CEG.S136803. PMID: 28761367; PMCID: PMC5522668.</ref>
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=== Note ===
=== Note ===
We could consider [[MTB, Mycobacterium tuberculosis|MTB]] and [[CMV, Cytomegalovirus|CMV]] as a good candidate miasm for IBD and Celiac disese
We could consider [[MTB, Mycobacterium tuberculosis|MTB]] and [[CMV, Cytomegalovirus|CMV]] as a good candidate miasm for [[IBD, Inflammatory bowel disease|IBD]] and [[Celiac disease]]
<references />
<references />

Latest revision as of 00:32, 8 December 2023

Clinic

  • PLE is a kind of Enteropathy, refers to any condition of the GI tract that results in a net loss of protein from the body.
  • Signs/ Symptoms are Diarrhea, Fever, and Abdominal discomfort.
  • Swelling of the legs due to peripheral edema
  • PLE is related to a systemic disease such as congestive heart failure or constrictive pericarditis.


Causes

  • Congenital heart defect (single ventricle following surgical repair resulting in congestive heart failure)
  • Idiopathic ulcerative jejunoileitis
  • Neoplasm (Secondary obstruction)
  • Ménétrier's disease
  • Zollinger-Ellison syndrome
  • Common variable immunodeficiency (CVID)
  • Primary intestinal lymphangectasia

Types

PLE in relation to the associated pathology for three different disease categories: [2]

  1. Increased lymphatic pressure (e.g., lymphangiectasis)
  2. Diseases with mucosal erosions (e.g., Crohn’s disease)
  3. Diseases without mucosal erosions (e.g., Celiac disease)

Note

We could consider MTB and CMV as a good candidate miasm for IBD and Celiac disease

  1. ↑ Front. Pediatr., 30 May 2022 Sec. Pediatric Gastroenterology, Hepatology and Nutrition Volume 10 - 2022 | https://doi.org/10.3389/fped.2022.875032
  2. ↑ Levitt DG, Levitt MD. Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states. Clin Exp Gastroenterol. 2017 Jul 17;10:147-168. doi: 10.2147/CEG.S136803. PMID: 28761367; PMCID: PMC5522668.
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