Wernicke Encephalopathy: Difference between revisions
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Oldver>Mehrdad (Created page with "=== Clinic === * Other names: Wernicke encephalopathy (WE), also Wernicke's encephalopathy, or wet brain * WE is the presence of neurological symptoms caused by biochemical lesions of CNS after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1). * WE is part of a larger group of thiamine deficiency disorders that includes beriberi, in all its forms, and alcoholic Korsakoff syndrome. * When it occurs simultaneously with alcoholic Korsakoff syndrome it...") |
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Latest revision as of 04:05, 23 March 2023
Clinic
- Other names: Wernicke encephalopathy (WE), also Wernicke's encephalopathy, or wet brain
- WE is the presence of neurological symptoms caused by biochemical lesions of CNS after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).
- WE is part of a larger group of thiamine deficiency disorders that includes beriberi, in all its forms, and alcoholic Korsakoff syndrome.
- When it occurs simultaneously with alcoholic Korsakoff syndrome it is known as Wernicke–Korsakoff syndrome.
Sign / Symptoms
- Classically, WE is characterised by a triad of symptoms:
- Ophthalmoplegia
- Ataxia
- Confusion
- Around 10% of patients exhibit all three features, and other symptoms may also be present.Others including:
- Pupillary changes, retinal hemorrhage, papilledema, impaired vision and hearing, vision loss
- Hearing loss,
- Fatigability, apathy, irritability, drowsiness, psycho and/or motor slowing
- Dysphagia, blush, sleep apnea, epilepsy and stupor
- Lactic acidosis
- Memory impairment, amnesia, depression, psychosis
- Hypothermia, polyneuropathy, hyperhidrosis