Acute motor axonal neuropathy: Difference between revisions
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Oldver>Mehrdad (Created page with "=== Clinic === * AMAN form of the Guillain-Barre syndrome * It is a paralytic disorder of abrupt onset characterized pathologically by ** Only Motor nerve fiber degeneration of variable severity ** No sensory fibers involvement * There is little demyelination or lymphocytic inflammation. * Most cases have antecedent infection with Campylobacter jejuni and many have antibodies directed toward GM1 ganglioside-like epitopes. * The mecha...") |
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Latest revision as of 03:01, 23 March 2023
Clinic
- AMAN form of the Guillain-Barre syndrome
- It is a paralytic disorder of abrupt onset characterized pathologically by
- Only Motor nerve fiber degeneration of variable severity
- No sensory fibers involvement
- There is little demyelination or lymphocytic inflammation.
- Most cases have antecedent infection with Campylobacter jejuni and many have antibodies directed toward GM1 ganglioside-like epitopes.
- The mechanism has not been defined.
- Possibly AMAN is a novel disorder caused by an antibody- and complement-mediated attack on the axolemma of motor fibers. [1]
- ↑ Hafer-Macko C, Hsieh ST, Li CY, Ho TW, Sheikh K, Cornblath DR, McKhann GM, Asbury AK, Griffin JW. Acute motor axonal neuropathy: an antibody-mediated attack on axolemma. Ann Neurol. 1996 Oct;40(4):635-44. doi: 10.1002/ana.410400414. PMID: 8871584.