Protein losing enteropathy

Clinic

• PLE is a kind of Enteropathy, refers to any condition of the GI tract that results in a net loss of protein from the body.
• Signs/symptoms are Diarrhea, Fever, and General abdominal discomfort.
• Swelling of the legs due to peripheral edema can also occur, however,
• If PLE is related to a systemic disease such as congestive heart failure or constrictive pericarditis, then the symptoms could be of the primary disease development.

Causes

• IBD (Crohn’s disease)
• Congenital heart defect (single ventricle following surgical repair resulting in congestive heart failure)
• Idiopathic ulcerative jejunoileitis
• MTB: Protein-Losing Enteropathy in Association With Tuberculosis-Related Constrictive Pericarditis.
• Neoplasm (secondary obstruction)
• Sarcoidosis (secondary obstruction).
• Amyloidosis
• SLE
• Ménétrier's disease
• Zollinger-Ellison syndrome
• Eosinophilic gastroenteritis
• Coeliac disease
• Common variable immunodeficiency (CVID)
• Primary intestinal lymphangectasia

Types

PLE in relation to the associated pathology for three different disease categories:

1. Increased lymphatic pressure (e.g., lymphangiectasis)
2. Diseases with mucosal erosions (e.g., Crohn’s disease)
3. Diseases without mucosal erosions (e.g., Celiac disease)

Note

We could consider MTB and CMV as a good candidate miasm for IBD and Celiac disese