Protein losing enteropathy

Clinic

• PLE is a kind of Enteropathy, refers to any condition of the GI tract that results in a net loss of protein from the body.
• Signs/ Symptoms are Diarrhea, Fever, and Abdominal discomfort.
• Swelling of the legs due to peripheral edema
• PLE is related to a systemic disease such as congestive heart failure or constrictive pericarditis.

Causes

Amyloidosis Coeliac disease Eosinophilic gastroenteritis IBD (Crohn’s disease) MTB: PLE in Association With Tuberculosis-Related Constrictive Pericarditis. Sarcoidosis (Secondary obstruction). SLE	Congenital heart defect (single ventricle following surgical repair resulting in congestive heart failure) Idiopathic ulcerative jejunoileitis Neoplasm (Secondary obstruction) Ménétrier's disease Zollinger-Ellison syndrome Common variable immunodeficiency (CVID) Primary intestinal lymphangectasia

Types

PLE in relation to the associated pathology for three different disease categories:

1. Increased lymphatic pressure (e.g., lymphangiectasis)
2. Diseases with mucosal erosions (e.g., Crohn’s disease)
3. Diseases without mucosal erosions (e.g., Celiac disease)

Note

We could consider MTB and CMV as a good candidate miasm for IBD and Celiac disease