Mononeuropathy

Clinic

• Mononeuropathy is opposit of polyneuropathy
• It could be due to localized trauma (Static Cause)
  • Carpal tunnel syndrome
  • Axillary nerve palsy
• Infection.(Dynamic Cause)

Types

• Axillary nerve dysfunction
• Carpal tunnel syndrome
• Common peroneal nerve dysfunction
• Cranial mononeuropathy
• Femoral neuropathy
• Radial nerve dysfunction
• Ulnar nerve dysfunction
• Unilateral foot drop
• Sciatic nerve dysfunction
• Thoracic/lumbar radiculopathy

Autoimmune peripheral neuropathies

• Peripheral nervous system axons and myelin have unique potential protein, proteolipid, and ganglioside antigenic determinants. Despite the existence of a blood-nerve barrier, both humoral and cellular immunity can be directed against peripheral axons and myelin. Molecular mimicry may be triggered at the systemic level, as was best demonstrated in the case of bacterial oligosaccharides. The classification of immune neuropathy has been expanded to take into account specific syndromes that share unique clinical, electrophysiological, prognostic and serological features.
• Guillain-Barré syndrome encompasses a classical syndrome of acute demyelinating polyradiculoneuropathy and many variants:
  • Axonal motor and sensory
  • Axonal motor
  • Miller-Fisher
  • Autonomic
  • Sensory
  • Miller-Fisher syndrome with anti-GQ1b,
  • Multifocal motor neuropathy with anti-GM1, and
  • Distal acquired symmetric neuropathy with anti-MAG antibodies