Protein losing enteropathy
Jump to navigation
Jump to search
Clinic
- PLE is a kind of Enteropathy, refers to any condition of the GI tract that results in a net loss of protein from the body.
- Signs/symptoms are Diarrhea, Fever, and General abdominal discomfort.
- Swelling of the legs due to peripheral edema can also occur, however,
- If PLE is related to a systemic disease such as congestive heart failure or constrictive pericarditis, then the symptoms could be of the primary disease development.
Causes
- IBD (Crohn’s disease)
- Congenital heart defect (single ventricle following surgical repair resulting in congestive heart failure)
- Idiopathic ulcerative jejunoileitis
- MTB: Protein-Losing Enteropathy in Association With Tuberculosis-Related Constrictive Pericarditis. [1]
- Neoplasm (secondary obstruction)
- Sarcoidosis (secondary obstruction).
- Amyloidosis
- SLE
- Ménétrier's disease
- Zollinger-Ellison syndrome
- Eosinophilic gastroenteritis
- Coeliac disease
- Common variable immunodeficiency (CVID)
- Primary intestinal lymphangectasia
Types
PLE in relation to the associated pathology for three different disease categories: [2]
- Increased lymphatic pressure (e.g., lymphangiectasis)
- Diseases with mucosal erosions (e.g., Crohn’s disease)
- Diseases without mucosal erosions (e.g., Celiac disease)
Note
We could consider MTB and CMV as a good candidate miasm for IBD and Celiac disese
- ↑ Front. Pediatr., 30 May 2022 Sec. Pediatric Gastroenterology, Hepatology and Nutrition Volume 10 - 2022 | https://doi.org/10.3389/fped.2022.875032
- ↑ Levitt DG, Levitt MD. Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states. Clin Exp Gastroenterol. 2017 Jul 17;10:147-168. doi: 10.2147/CEG.S136803. PMID: 28761367; PMCID: PMC5522668.