This is a state of disliking for anything where one feels that in him no further room is left for even a little liking further for the thing, in question. Rather it has crossed the limits of acceptancy where he is nauseating and is on the verge of vomiting.
Versions
I am fed up of taking medicine daily. I feel like stopping it for some time. Please tell me for how long more. I shall have to take it.
When shall I can get rid of this disease? I am so fed up the Doctor, I cannot tell you.