PERM, Progressive encephalomyelitis with rigidity and myoclonus entities

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Revision as of 07:55, 17 October 2022 by Oldver>Mehrdad (Created page with "=== Clinic === PERM is a rare and severe neurological syndrome characterized by '''muscular rigidity''' and '''spasms''' as well as brain stem and '''autonomic dysfunction'''. It can be associated with anti-GAD, GlyR, and DPPX antibodies. All of these autoantibodies may be variably associated with malignant tumors and their response to immunotherapy, as well as to tumor removal, is not easily predictable. === Miasms === * Myoclonous, Rigidity * Autonomic dysfunctio...")
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Clinic

PERM is a rare and severe neurological syndrome characterized by muscular rigidity and spasms as well as brain stem and autonomic dysfunction.

It can be associated with anti-GAD, GlyR, and DPPX antibodies.

All of these autoantibodies may be variably associated with malignant tumors and their response to immunotherapy, as well as to tumor removal, is not easily predictable.

Miasms

  • Myoclonous, Rigidity
  • Autonomic dysfunction
  • Myelitis, Multiple sclerosis

HTLV-1

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