PERM, Progressive encephalomyelitis with rigidity and myoclonus entities
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Clinic
PERM is a rare and severe neurological syndrome characterized by muscular rigidity and spasms as well as brain stem and autonomic dysfunction.
It can be associated with anti-GAD, GlyR, and DPPX antibodies.
All of these autoantibodies may be variably associated with malignant tumors and their response to immunotherapy, as well as to tumor removal, is not easily predictable.
Miasms
- Myoclonous, Rigidity
- Autonomic dysfunction
- Myelitis, Multiple sclerosis