Polyneuropathy

Clinic

• "Polyneuropathy" is a pattern of nerve damage that is quite different from mononeuropathy, often more serious and affecting more areas of the body.
• The term "peripheral neuropathy" sometimes is used loosely to refer to polyneuropathy.
• In cases of polyneuropathy, many nerve cells in various parts of the body are affected, without regard to the nerve through which they pass; not all nerve cells are affected in any particular case.
• Four common types
  1. Distal axonopathy: Neural cell bodies remain intact, but axons esp longest axons are affected. Diabetic neuropathy is the most common cause.
  2. Demyelinating polyneuropathies: Myelin sheath is damaged, which affects the ability of the axons to conduct electrical impulses.
  3. Sensory neuronopathy or Dorsal root ganglionopathy: Sensory neural cell bodies are affected
  4. Motor neuron disease: Motor neural cell bodies are affected

Symptoms

• Motor symptoms
  • Weakness
  • Clumsiness of movement
• Sensory symptoms such as
  • Unusual or unpleasant sensations such as tingling or burning
  • Reduced sensations of texture or temperature
• Impaired balance when standing or walking.
• Autonomic symptoms also may occur, such as
  • Dizziness on standing up
  • Erectile dysfunction
  • Difficulty controlling urination

Causes

Dynamic	Static
Lyme disease	Diabetic neuropathy Vitamin deficiencies Blood disorders Toxins

Entity /Miams

• Brachial Plexopathy:
• Lumbar Radiculopathy: HSV-1, HSV-2, LBB
• Peripheral Neuropathy: B19, HIV
• Neuropathy, sensory loss: B19, HIV
• Neuritis:
  • Glosopharyngeal and Vagus: VZV
  • Radicular: TBE
  • Retrobulbar: EBV
  • Vestibular