Parkinson's disease dementia

Clinic

• PDD is dementia that is associated with Parkinson's disease (PD).
• Together with dementia with Lewy bodies (DLB), it is one of the Lewy body dementias characterized by abnormal deposits of Lewy bodies in the brain.
• PD starts as a movement disorder, but progresses in most cases to include dementia, and changes in mood and behavior.
• The signs, symptoms and cognitive profile of PDD are similar to those of DLB
• DLB and PDD are clinically similar after dementia occurs in Parkinson's disease.
• PD is a risk factor for PDD; it speeds up decline in cognition leading to PDD.
• Up to 78% of people with PD have dementia.

PDD vs DBL

	PDD	DBL
Visual hallucinations	Less	More
Tremor	More	Less
Parkinsonism	Symmetric	Asymmetric
Delusions	Less	More

PDD Black Box

	JE	CJD
Parkinsonism	+++	+++
Dementia	+++	+++
Psychosis	+++	+++