Acute motor axonal neuropathy

Clinic

• AMAN form of the Guillain-Barre syndrome
• It is a paralytic disorder of abrupt onset characterized pathologically by
  • Only Motor nerve fiber degeneration of variable severity
  • No sensory fibers involvement
• There is little demyelination or lymphocytic inflammation.
• Most cases have antecedent infection with Campylobacter jejuni and many have antibodies directed toward GM1 ganglioside-like epitopes.
• The mechanism has not been defined.
• Possibly AMAN is a novel disorder caused by an antibody- and complement-mediated attack on the axolemma of motor fibers.