Anti-DPPX Encephalitis
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Clinic
- Episode of diarrhea, which was followed by tremor, disorientation, and mild memory impairment.
- Anti-DPPX-IgG- is known to increase the excitability and action potential frequency of guinea pig and human enteric nervous system neurons.[1]
- In other 2017 study, Nine new patients is presented with severe prodromal weight loss or diarrhea followed by
- Cognitive dysfunction (100%),
- Memory deficits (55%),
- CNS hyperexcitability (88%) including Hyperekplexia, Myoclonus, Tremor, or Seizures
- Brainstem or cerebellar dysfunction (77%)
- Triad (67%)
- Weight loss (median 20 kg) / Gastrointestinal symptoms
- Cognitive-mental dysfunction
- CNS hyperexcitability.[2]
- ↑ Piepgras J, Höltje M, Michel K, Li Q, Otto C, Drenckhahn C, Probst C, Schemann M, Jarius S, Stöcker W, Balint B, Meinck HM, Buchert R, Dalmau J, Ahnert-Hilger G, Ruprecht K. Anti-DPPX encephalitis: pathogenic effects of antibodies on gut and brain neurons. Neurology. 2015 Sep 8;85(10):890-7. doi: 10.1212/WNL.0000000000001907. Epub 2015 Aug 19. PMID: 26291285; PMCID: PMC4560062.
- ↑ Hara M, Ariño H, Petit-Pedrol M, Sabater L, Titulaer MJ, Martinez-Hernandez E, Schreurs MW, Rosenfeld MR, Graus F, Dalmau J. DPPX antibody-associated encephalitis: Main syndrome and antibody effects. Neurology. 2017 Apr 4;88(14):1340-1348. doi: 10.1212/WNL.0000000000003796. Epub 2017 Mar 3. PMID: 28258082; PMCID: PMC5379928.