Anti-MOG associated encephalomyelitis entities
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Clinic
Serum anti-myelin oligodendrocyte glycoprotein antibodies are present in up to 50% of patients with an acquired demyelinating syndrome including:
- ADEM
- Optic neuritis
- Transverse myelitis
- Rett syndrome: An interesting point is that it has recently been found that this type of encephalitis mimics the image of Rett syndrome. [1]
- Seroneative neuromyelitis optica
- MS
- CRION (chronic relapsing inflammatory optic neuropathy).
- Aseptic meningitis and meningoencephalitis (typically post-infectious)
- Tumefactive demyelination: Rare cases of anti-MOG antibodies in association with tumefactive multiple sclerosis have been described
Symptoms [2]
The signs and symptoms of anti-MOG associated disease are based on which part of the nervous system is affected.
Children presenting with ADEM or autoimmune encephalitis may have
- Confusion, a decreased level of alertness,
- Seizures,
- Behavioral changes,
- Optic neuritis + Pain around the eyes.
- Transverse myelitis can cause Weakness, Numbness, Difficulty walking and bowel/bladder function.
Miasms:
Analogue:
Anti-GQ1b antibody syndrome entities: Both have same mechanism (Myelitis) with different location due to different Antigen sites. Its main miasm is SHBV and the second one is STLE
- ↑ Anti-MOG antibody encephalitis mimicking neurological deterioration in a case of Rett syndrome with MECP2 mutation Hiroo Tani
- ↑ https://www.childrens.com/specialties-services/conditions/antibody-associated-disorder#:~:text=The%20signs%20and%20symptoms%20of%20anti%2DMOG%20associated%20disease%20are,numbness%2C%20weakness%20or%20difficulty%20walking.