Autoimmune peripheral neuropathies

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Clinic

  • Peripheral nervous system axons and myelin have unique potential protein, proteolipid, and ganglioside antigenic determinants.
  • Guillain-Barré syndrome encompasses a classical syndrome of acute demyelinating polyradiculoneuropathy and many variants:
    • Axonal motor and sensory
    • Miller-Fishe
  • Miller-Fisher syndrome with anti-GQ1b
  • Multifocal motor neuropathy with anti-GM1
  • Distal acquired symmetric neuropathy with anti-MAG antibodies [1]
  1. Bourque PR, Chardon JW, Massie R. Autoimmune peripheral neuropathies. Clin Chim Acta. 2015 Sep 20;449:37-42. doi: 10.1016/j.cca.2015.02.039. Epub 2015 Mar 4. PMID: 25748038.