Endotheliopathy miams

Physiology

• The endothelium, the cell layer lining blood vessels is not a passive conduit, but can rather be thought of as an organ that interacts with both blood components as well as vascular smooth muscle

• In this role, the endothelium is crucial for regulation and modulation of immune responses, coagulation, and vascular smooth muscle tone

• Endothelial cells release factors such as Nitric oxide, Endothelins, prostacyclin, and Von Willebrand factor (vWF)

• Endothelial cell characteristics and functions vary by organ (and sometimes within the same organ)
• The pathophysiological understanding of atherosclerosis has gone through several stages. Today, it is understood as an Inflammatory/ Proliferative disease.
• Endothelial dysfunction plays a central role in the formation of atherosclerotic plaque, in its progression, and in complications.

Pathophysiology

• Hemolytic Uremic Syndrome (HUS)
• Thrombotic Thrombocytopenic Purpura (TTP)
• Disemminated Intravsacular Coagulation (DIC)
• Thrombocytopenia Associated Multiple Organ Failure (TAMOF)
• Sepsis