Enteropathy associated T cell lymphoma
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Clinic
- EATL previously termed enteropathy-associated T-cell lymphoma, type I and at one time termed enteropathy-type T-cell lymphoma (ETTL)
- It is a complication of coeliac disease in which a malignant T-cell lymphoma develops in areas of the small intestine affected by the disease's intense inflammation.
- EATL is a relatively rare disease, it is the most common type of primary gastrointestinal T-cell lymphoma.
- Typically occurs in patients with a history of coeliac disease and who may have been previously diagnosed with Type I or II refractory disease, but in any case, affected individuals present with worsening coeliac disease symptoms of abdominal pain, malabsorption, diarrhea, weight loss, fever or night sweats.
- EATL diagnosis is more likely if symptoms develop suddenly, or if the serious symptoms of bowel obstruction and/or bowel perforation caused by bulky EATL masses develop.
- Patients with ulcerative jejunitis usually present with more severe symptoms, including more frequent bowel perforations and obstructions. Some patients with no history of coeliac disease present with symptoms or signs of a small-intestinal lymphoma but on diagnostic workup are found to have coeliac disease
Miasms
- ↑ Pan L, Diss TC, Peng H, Lu Q, Wotherspoon AC, Thomas JA, Isaacson PG. Epstein-Barr virus (EBV) in enteropathy-associated T-cell lymphoma (EATL). J Pathol. 1993 Jun;170(2):137-43. doi: 10.1002/path.1711700207. PMID: 8393922.