Eosinophilic granulomatosis with polyangiitis
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Clinic
- EGPA, formerly known as allergic granulomatosis, is an extremely rare autoimmune condition that causes vasculitis of small and medium-sized blood vessels in persons with a history of airway allergic hypersensitivity (atopy).
- It usually manifests in three stages.
- Early stage is marked by airway inflammation; almost all patients experience asthma and/or allergic rhinitis.
- Second stage is characterized by Hypereosinophilia, which causes tissue damage, most commonly to the lungs and the digestive tract.
- Third stage consists of vasculitis
Signs and symptoms
- Allergic stage: Asthma, Allergic rhinitis, Nasal polyps and Sinusitis
- Eosinophilic stage: Weight loss, Night sweats, Asthma, Cough, Abdominal pain, GI bleeding, Fever, Malaise
- Vasculitic stage:Peritonitis , Ulcerations / Perforations of GI tract due to acalculous cholecystitis or granulomatous appendicitis, Myocarditis, Pericardial tamponade, Glomerulonephritis
Entities
- Vasculitis
- Respiration, Wheezing
- Eosinophilia