Eosinophilic granulomatosis with polyangiitis

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Clinic

  • EGPA, formerly known as allergic granulomatosis, is an extremely rare autoimmune condition that causes vasculitis of small and medium-sized blood vessels in persons with a history of airway allergic hypersensitivity (atopy).
  • It usually manifests in three stages.
    1. Early stage is marked by airway inflammation; almost all patients experience asthma and/or allergic rhinitis.
    2. Second stage is characterized by Hypereosinophilia, which causes tissue damage, most commonly to the lungs and the digestive tract.
    3. Third stage consists of vasculitis


Signs and symptoms

  • Allergic stage: Asthma, Allergic rhinitis, Nasal polyps and Sinusitis
  • Eosinophilic stage: Weight loss, Night sweats, Asthma, Cough, Abdominal pain, GI bleeding, Fever, Malaise
  • Vasculitic stage:Peritonitis , Ulcerations / Perforations of GI tract due to acalculous cholecystitis or granulomatous appendicitis, Myocarditis, Pericardial tamponade, Glomerulonephritis

Entities


Miasms

MTB