Frontotemporal lobar degeneration

Clinic

• FTLD is a pathological process that occurs in frontotemporal dementia. It is characterized by atrophy in the frontal lobe and temporal lobe of the brain, with sparing of the parietal and occipital lobes.
• Common proteinopathies that are found in FTLD include the accumulation of tau proteins and TAR DNA-binding protein 43 (TDP-43)

Subtypes

Three clinical subtypes of FTLD are

• Frontotemporal dementia which mainly affects a frontomedian network discussed in the context of social cognition.
• Semantic dementia which mainly related to the inferior temporal poles and amygdalae; brain regions that have been discussed in the context of conceptual knowledge, semantic information processing, and social cognition
• Progressive nonfluent aphasia which affects the whole left frontotemporal network for phonological and syntactical processing.