Insulin Autoimmune Syndrome

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Clinic

  • Insulin autoimmune syndrome is a rare condition that causes hypoglycemia.
  • This occurs because the body begins to make a specific kind of protein called antibodies to attack insulin.
  • IAS also named Hirata’s disease, is a rare condition characterized by hypoglycemic episodes due to the presence of high titers of insulin autoantibodies (IAA).
  • IAS is a form of immune-mediated hypoglycemia, which develops when a triggering factor (ie, a medication or a viral infection) acts on an underlying predisposing genetic background.
  • Secondly, IAS can be classified according to the association with other autoimmune diseases
  • IAS can be associated with other autoimmune diseases, being included in type 3A or in type 4 autoimmune polyendocrine syndrome
  • IAS and Graves’ disease that was originally identified9 has been subsequently clarified:11,29 these two different autoimmune diseases may be associated not as independent manifestations of a common autoimmune condition, but because IAS may be the consequence of the exposure to antithyroid drugs administered to the patient for the cure of the hyperthyroidism.


Causes

  • MMP
  • RBL,
  • CXB
  • INFL,
  • HCV,
  • VZV
  • RBOL [1]
  1. Simona Censi, Caterina Mian, Corrado Betterle Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Padova, Italy