KRU, Kuru

Kuru is the first human transmissible spongiform encephalopathy (TSE) or prion miasm identified
It is a uniformly fatal cerebellar ataxic syndrome, usually followed by choreiform and athetoid movements.

Ref: J Neuropathol Exp Neurol. Author manuscript; available in PMC 2016 Nov 23. J Neuropathol Exp Neurol. 2012 Feb; 71(2): 92–103.

Its important regions are Mind and CNS.
KRU is a very rare, incurable and fatal neurodegenerative disorder that was formerly common among the Fore people of Papua New Guinea.
KRU is a form of (TSE) which leads to tremors and Incoordination.
Body tremors is a classic symptom of the disease (Titubation /Nodding movement of the head or body)
It is also known as the "laughing sickness" due to the pathologic bursts of laughter

First stage
- Unsteady stance and gait
- Decreased muscle control
- Dysarthria
- Tremors
Second stage
- Incapable of walking without support and experiences
- Ataxia
- Severe tremors
- Emotional instability / Uncontrolled and sporadic laughter
- Depression
- Tendon reflexes are still intact at this stage of the disease.
Third stage
- Ataxia progress to the point where it is no longer possible to sit up without support
- Dysphagia
- Inability to speak
- Unresponsive to their surroundings despite maintaining consciousness
- Chronic ulcerated wounds that can be easily infected
- Pneumonia or other secondary infections.

Psychosis: Behavioral change
Cerebellar Ataxia/ Ataxia: Tremor, Incoordination, Dysarthria, Dysphagia, Gait abnormality
Pneumonia
Generality: Arthralgia, Weakness, Headache
Sensory loss
Choraoathetosis
Cranial nerve Palsies / Deficits
LMN: Myoclonic Jerking + Fasciculation + Muscular Weakness
Mutism, Apathy, Depression
Emotional instability
Hypotonia

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