LGI1 encephalitis

Clinic

• Leucine-rich glioma-inactivated-1 antibody encephalitis is an autoimmune encephalitis
• Patients may present with subacute onset of memory loss, behavioral disturbances and seizures.
• Peripheral manifestations, such as neuropathy or autonomic dysfunction, often coexist but may also occur without central involvement.
• Faciobrachial dystonic seizure (FBDS)
• Paroxysmal dizziness spells without alteration of consciousness

2 Entities

• Memory loss
• Behavior change
• Seizure
• Dystonia (Rigidity + ChoreAthetosis)
• Hypertention

3 Miasms

JE