PML, Progressive multifocal leukoencephalopathy entities

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Clinic

  • PML is a rare fatal viral disease characterized by Progressive Multi local inflammation of the white matter of brain.
  • It is caused by the JCV, almost exclusively in AIDS. [1]


Signs and symptoms

  • Clumsiness
  • Progressive weakness
  • Visual changes
  • Speech changes
  • Personality changes
  • Psychosis [2]


Related disease

  • Hodgkin's lymphoma
  • Autoimmune diseases (MS, SLE, RA, Psoriasis)
  • Lesions affecting the parietal and occipital lobes of the brain can lead to a phenomenon known as alien hand syndrome
  • HIV-1 infection / acquired immune deficiency syndrome (AIDS)
  1. https://www.ninds.nih.gov/health-information/disorders/progressive-multifocal-leukoencephalopathy#:~:text=Publications-,Definition,insulates%20nerve%20cells%20(neurons).
  2. Walker, Bryan L. and Holt, Christina MD, MSc (2019) "Signs of Psychosis Leading to a Diagnosis of Progressive Multifocal Leukoencephalopathy: A Case Report," Journal of Maine Medical Center: Vol. 1 : Iss. 1 , Article 11.