Polyarteritis nodosa

PAN is a systemic necrotizing vasculitis affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation.
Small aneurysms are strung like the beads of a rosary, therefore making this "rosary sign" an important diagnostic feature of the vasculitis.
PAN is sometimes associated with HBV and HCV

PAN may affect nearly every organ system and thus can present with a broad array of signs and symptoms.
Manifestations result from ischemic damage to affected organs, often the skin, heart, kidneys, and nervous system.
Constitutional symptoms are seen in up to 90% of affected individuals and include fever, fatigue, weakness, loss of appetite, and unintentional weight loss.
Rashes, swelling, necrotic ulcers, and subcutaneous nodules
Palpable purpura and livedo reticularis
Peripheral neuropathy: Numbness, pain, burning, and weakness
- Mononeuritis multiplex (70%) Because of damage to arteries supplying large peripheral nerves.
- Asymmetric polyneuropathy
Seizures
Renal artery Vasculitis causesRenal artery narrowing /Thrombosis / Infractions, which leads to high blood pressure, deposition of protein or blood in the urine and renal insufficiency

Vasculitis of mesenteric arteries can cause abdominal pain, mesenteric ischemia, and bowel perforation. Abdominal pain

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