Pure Autonomic Failure

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Clinic

  • PAF is a neurodegenerative disorder of the autonomic nervous system clinically characterized by orthostatic hypotension.
  • It has also been known as Bradbury-Eggleston syndrome
  • Autonomic failure may also manifest as genitourinary, bowel, and thermoregulatory dysfunction.
  • Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein.
  • PAF may progress into other synucleinopathies with CNS involvement [1]

Miasm

Same as Neurogenic Syncope

  1. ↑ https://www.mayoclinicproceedings.org/article/S0025-6196(19)30265-4/fulltext#:~:text=Pure%20autonomic%20failure%20(PAF)%20is,of%20the%201925%20seminal%20description.
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