View source for MS, Multiple Sclerosis

=== Clinic ===

* MS is a demyelinating autoimmune disease of nervous system.
{| class="wikitable"
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!Specific symptoms:
!Related disease
!MS types
|-
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* Double vision / Blindness in one eye
* Muscle weakness
* Trouble with sensation
* Incoordination
* Cognitive disturbance
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*[[GBS, Guillian Barre syndrome|GBS]]
* [[ADEM, Acute disseminated encephalomyelitis entities|Acute disseminated encephalomyelitis]]
* [[Subacute sclerosing panencephalitis]]
|I think MS is an umbrella covering a list of demyelinating disease. I suggest a new classification Considering sign / Symptoms which equals the localization of demyelination.
* Autonomic
* Visual
* Motor
* Sensory
* Vestibular
* Cerebellar
|}

=== Miasmatic analysis ===
In order to find appropriate miasm, I need to know series of miasms which could cause Encephalomyelitis. Then the localized involvement could specialized the miasm. [[ADEM, Acute disseminated encephalomyelitis entities|ADEM]]  could be a good choice.
{| class="wikitable"
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!
=== MS types ===
 
!Pathology
!Sign / Symptoms
!Entities
!Miasms
!Suggested 
Remedies
|-
|'''<big>Vestibular MS</big>''' 
(49–59%)
|Intra-pontine 8th nerve fascicle involvement= Acute Vestibular Syndrome (AVS)
|
* Vertigo, dizziness Imbalance
* Impaired functional ability, contribute to falls and significant health and social care costs
|
*[[ADEM, Acute disseminated encephalomyelitis entities|ADEM]]
* [[Ataxia]]
* [[Vertigo]] or Dizziness
|
* [[VZV, Varicella Zoster Virus|VZV]] for vertigo
* [[STLE, St Louis Encephalitis|STLE]] for dizziness
|[[Gels, Gelsemium sempervirens|Gels]]
[[Alum, Alumina|Alum]]
|-
| rowspan="4" |'''<big>Autonomic MS</big>'''

|<br />Cardiovascular / Thermoregulatory function during exercise
Due to Hypothalamus temperature regulation disorder.
|
*[[Uhthoff's sign]]: Agg from higher than usual temperatures
* Attenuated elevations in blood pressure during exercise can negatively impact blood flow to skeletal muscle.
* Diminished sweating during exercise 
|
*[[ADEM, Acute disseminated encephalomyelitis entities|ADEM]] / [[Subacute sclerosing panencephalitis|SSPE]]
* [[Thermoregulatory disorder|Thermoregulation impaired]]
|[[RBOL, Measles, rubeola|RBOL]]
|
|-
|Bowel MS:
Bowel accidents can also be caused by reduced sensation in back passage, so he dose not recognize the urge to go to the toilet, and reduced control of the muscles at the bottom of his anus.
|
*[[Constipation]] due to Decreased or slowed Bowel motility.
* Hard plug of impacted stool builds up in the back passage, 
* Overflow incontinence: A loose, watery stool can leak out
|
* [[Constipation]]
* Involuntary stool
|
* [[HSV-1, Herpes Simplex Virus|HSV-1]]
* [[HSV-2, Herpes Simplex Virus|HSV-2]]
|[[Alum, Alumina|Alum]]
|-
|'''Bladder MS:'''Urge incontinence (8%): Spastic/ Overactive bladder: 
|
*Incontinence: Unable to hold urine
* Frequency / Urgency
* Hesitancy / Difficulty in starting urination
|
* ADEM / Brain-stem
* Incontinence
* Frequency / Urgency
|
* [[HTLV-1, Human T lymphotropic virus type 1|HTLV-1]]
* [[STLE, St Louis Encephalitis|STLE]]
|[[Caust, Causticum|Caust]]
|-
|'''Bladder MS:'''
Overflow

* Bladder that does not empty properly 
* Nocturia

|Bladder does not empty properly (retains some urine in it)
|
* [[ADEM, Acute disseminated encephalomyelitis entities|ADEM]]
* Bladder/Atonia
|[[HSV-1, Herpes Simplex Virus|HSV-1]]
|
|-
|[[Upper motor neuron, UMN|'''<big>UMN</big>''']]
'''<big>MS</big>'''
|Corticospinal tract involvement
|
|
*ADEM
* Spasticity
* Paralysis/Weakness:
* Hyper Reflexia
* Reflexes, Primitive
|
* [[HTLV-1, Human T lymphotropic virus type 1|HTLV-1]]
* HIV
|
* Arg-n
* Lat-s
* Plb
* [[Pic-ac, Picricum Acidum|Pic-ac]]
|-
|'''<big>Cerebellar MS</big>'''
|
|
|
*ADEM
* Tremor
* [[Cerebellar ataxia|Cerebellar Ataxia]]
* [[Dysarthria]]
|
* [[CXA, CXB, ECH, Coxsackie viruses & Echoviruses|CXB]]
* [[VZV, Varicella Zoster Virus|VZV]]
|Alum
Con
|-
|'''<big>Visual MS</big>'''
|Sudden visual loss
|
|ADEM / SSPE
[[Optic neuritis]]/Atrophy
|
* [[EBV, Epstein Barr Virus|EBV]]
* [[WNE, West Nile Encephalitis|WNE]]
* [[HTLV-1, Human T lymphotropic virus type 1|HTLV-1]]
* [[RBOL, Measles, rubeola|RBOL]]
|Gels
[[Phys, Physostigma Venenosum|Phys]]
|-
|'''<big>Cognitive MS</big>'''
|
*40-65 % Cognition skills such as
* Cognitive miasms: '''VZV, EBV,''' HHV-6, CMV, HSV-2, RBOL, HSV-1
* Aphasic Miasms: '''VZV'''
|
*Memory
* Attention span
* Information processing (Decision making, Problem solving)
* Visual-Spatial Abilities
* Verbal Fluency: Word-Hunting or mixing words
|
* ADEM / SSPE
* Cognition
* Concentration
* Memory
* [[Aphasia]]
|
* VZV
* EBV
* INFL
* MMP
|
|-
|'''<big>Painful MS</big>'''
|Central sensitization and second Hyper Stasia
|
* There are two different form first . It seems that both of them have same maiasmatic origin. 
* Central sensitization and sensory MS could be explained commonly.
|
*Hyper Stasia
*Dysesthesia
|
*HSV-1
*HSV-2
* HTLV-1
|[[Ox-ac, Oxalicum Acidum|Ox-ac]]
[[Pic-ac, Picricum Acidum|Pic-ac]] 
|}


=== Related disease ===
[[RBD, Rapid Eye Movement Sleep Behavior Disoder|RBD]] 

* Rapid eye movement sleep behavior disorder (RBD) is a parasomnia characterized by brief recurrent episodes of loss of muscle atonia during rapid eye movement sleep, with enacted dreams that cause sleep disruption. 
* MS patients have an increased risk compared with the general population to be affected by a sleep disturbance, including RBD. Patients affected, however, uncommonly can present RBD as the first clinical manifestation of MS without other neurologic deficits. These clinical presentations have usually been attributed to inflammatory lesions in the pedunculopontine nuclei, located in the dorsal pons. We present a case of RBD in a 38-year-old woman who was later diagnosed as having MS due to imaging findings and development of focal neurologic deficits. MS should be considered among the differential diagnoses in patients who present with symptoms of RBD, particularly if they are young and female.<ref>Enriquez-Marulanda A, Quintana-Peña V, Takeuchi Y, Quiñones J. ''Case Report:'' Rapid Eye Movement Sleep Behavior Disorder as the First Manifestation of Multiple Sclerosis: A Case Report and Literature Review. Int J MS Care. 2018 Jul-Aug;20(4):180-184. doi: 10.7224/1537-2073.2017-001. PMID: 30150902; PMCID: PMC6107341.</ref>

== Remedies ==
{| class="wikitable"
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!
!
!
!
|-
| rowspan="2" |'''<big>Prominent Eye Symptoms</big>'''
|
=== [[Phys, Physostigma Venenosum|Phys]] ===
|
* Dim vision, blurred vision
* Partial loss of vision and
* Trembling of vision
|
* C30

* Pain over orbits, cannot bear to rise eyelids.
* Spasm of ciliary muscles + Irritability after using eyes.
|-
| rowspan="2" |
=== [[Gels, Gelsemium sempervirens|Gels]] ===

* MS after Influenza
|
* [[Optic neuritis]] or Orbital neuralgia
* Blurred/ Foggy / Smoky vision,
* Double vision, 
* Varying degree of vision loss
* Dim sighted, pupils dilated and insensible to light.
|
*Pain in the eyes
*Contraction and twitching of muscles. 
*Blurring and discomfort in eyes even after accurately adjusted glasses.
*C200
|-
| rowspan="2" |'''<big>Difficulty in Balance /[[Incoordination]] / [[Ataxia]]</big>'''
|
* Lack of muscle Coordination/ Balance  due to MS.
* Gait is slow and unsteady.
* Loss of balance while walking
* Varying degrees of motor paralysis. 

* Paralysis of various groups of muscles about eyes, throat, larynx, extremities etc.
* '''Ptosis, eyelids heavy, patient can hardly open them with double vision.'''
* Muscular weakness. Loss of power of muscular control 
|
*C200
*Intense '''Dizziness''' /'''Drowsiness / Dullness'''
* General prostration + '''Trembling''' 
* Muscular weakness / Complete relaxation.
* Cramps in muscles 
* Profuse, clear, watery urine 
* Chilliness 
* Tremulousness.
* Partial paralysis of bladder
|-
|
=== [[Alum, Alumina|Alum]] ===
|
* Locomotor [[ataxia]]
* Sluggish and staggering gait,
* Tottering and falling on closing the eyes,
* Numbness and a bandaged feeling in the legs.
|
*C200
* Staggers on walking. Spinal degeneration and paralysis of lower limbs
* [[Romberg test]] positive
* [[Constipation]]
|-
| rowspan="2" |'''<big>Numbness, [[Paresthesia|Tingling]], Pin/Needle-like Sensations</big>'''
|
=== [[Ox-ac, Oxalicum Acidum|Ox-ac]] ===
|
* Extremities are involved in MS.
* Weak trembling hands and feet.
* Numbness extends from shoulders to finger tips.
* [[Low back pain|Backache]] with numbness: Pain Drawing/ Sharp / Shooting/ Lancinating / '''Spot pain'''  starting from spine and extend through limbs.
|
*Muscular prostration: Weakness and coldness in the lower limbs
* '''Thinking about pain, agg.'''
* C30
|-
|
=== [[Pic-ac, Picricum Acidum|Pic-ac]] ===
|
* Feel pin and needle pricks in their limbs.
* The limbs often feel 
* Marked Prostration/ Weakness / Tired / Heavy all over the body muscles and spasms from MS
* Weakness agg with exertion.
|
* C 30

* Worn out persons, both mentally and physically.
* Burning sensation along the spine.
|-
| rowspan="3" |'''<big>Weakness in Lower Limbs</big>'''
|
=== [[Con, Conium Maculatum|Con]] ===

* MS + Vertigo
* Begins in lower limb
|
* MS + muscular weakness, esp lower limbs.
* Weak and weary legs
* unsteady walk: Sudden loss of strength in walking
* Difficult gait and stiffness in legs.
* Weakness in calf muscles, Rigidity in calves
* Heaviness of limbs where the limbs feel as if they were made of wood and trembling legs
* Positive Romberg test:
* Trembling of all the limbs.
* Numbness of fingers and toes.
* Ms from Grief
|
*C200
*Old age problems of weakness,
* Debility,
* Urinary troubles,
* Weak memory
* Eye troubles: Dim sighted agg in artificial lights.
* Paralysis of ocular muscles.
* Heavy, weary, paralyzed and trembling unsteady hands.
|-
|
=== [[Arg-n, Argentum Nitricum|Arg-n]] ===
|
* With softening of spinal cord. ([[Myelomalacia]])
* Weakness, rigidity, or twisting in calf muscles.
* Walks and stands unsteadily. Legs feel as if made of wood or padded
* Trembling and numbness of limbs + General debility.
|
*N'''eurotic effects'''
* '''In-coordination, loss of control''' and '''want of balance'''
* '''Trembling''' in affected parts
* Great desire for sweets.
* Spots before eyes. Eye strain from sewing worse in warm room. Blurred vision.
|-
|
=== [[Plb, Plumbum Metallicum|Plb]] ===
|
* Paralysis of lower limbs.
* Paralysis of single muscles, chiefly of extensor, forearm or upper limb from centre to periphery + 
* Partial anesthesia or Excessive hyperesthesia preceded by pain.
* Pain in atrophied muscles + Colic
* Cramps in calves
* Stinging/ Tearing / Tingling/ Numbness
* Twitching/ Tremor
* [[Constipation]]
|
* C200
* Localized neuralgic pains with [[Neuralgia , Neurologic pain remedies|neuritis]].
* Eyes: Sudden loss of sight after fainting.
* Paralysis of single muscles. Cannot raise arms, can’t lift anything. Extension is difficult.
* Paralysis from overexertion of extensor muscles in piano players.
|-
| rowspan="2" |<big>'''[[Spasticity]]'''</big>
|
=== [[Lat-s, Lathyrus Sativus|Lat-s]] ===
|
* Spasticity is most marked in the legs.
* The legs feel extremely rigid, with a spastic gait.
* This is accompanied by trembling or tottering gait.
* Cramps in the legs
* Lower limbs and Gluteal muscles emaciation
|
* C30
* MS with spastic paralysis of lower limbs.
* [[Hyper reflexia|Reflexes are increased]].
* MS with softening of spinal cord.
|-
|
=== [[Nat-m, Natrium muriaticum|Nat-m]] ===
|
* '''MS with painful contractions of muscle of thigh.'''
* Ankles weak and turn easily.
* Coldness of legs with congestion of head, chest and stomach.
* '''Eyelid heavy.''' 
* Ms from Grief
|
*'''See sparks. Fiery zigzag lines running'''.
* Emaciated patient with great weakness and emaciation.
* Psychic causes of diseases and ill effects of grief, fright and anger. Consolation aggravates.
|-
|[[Urinary incontinence|'''<big>Urinary incontinence</big>''']]
|
=== [[Caust, Causticum|Caust]] ===
|
* C 200

* Involuntary passage of urine, on coughing , walking, blowing nose or sneezing
* Urine dribbles or passes slowly.
* Paralysis of bladder with involuntary urination on sneezing and coughing.
* Unsteady walking and easily falling.
* Weakness and progressive loss of muscular strength, causing paralysis of single organs or parts.
* Ms from Grief
|
*Tearing, drawing pains and severe weakness.
* Local paralysis: Vocal cords, tongue, eyelids, face, bladder and extremities.
* '''Paralysis of single parts of extremities + Dull, tearing pains + Loss of sensation'''.
* Impaired vision with sparks and dark spots before eyes.
* '''Ptosis''' and paralysis of extra ocular muscles.
* Restless legs at night with weak ankles.
* Amel by warmth especially heat of bed.
|-
|
|
=== [[Phos, Phosphorus|Phos]] ===
|
*Marked prostration and trembling, numbness + complete paralysis
* Sensory and motor paralysis from ends of fingers and toes.
* Weakness and trembling from every exertion.
* Arms and hands become numb.
* Can scarcely hold anything.
* Ms from Grief
|
*'''Black points seem to float before the eyes.'''
* Fatigue of eyes and head with hands.
* Sensitives to external impressions like light, sound, touch and thunders.
|-
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=== Other remedies ===
|
*[[Zinc, Zincum Metallicum|Zinc]]
* [[Cupr, Cuprum metallicum|Cupr]]
* [[Syph, Syphilinum|Syph]]
* [[Cic, Cicuta Virosa|Cic]]
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|}
Homeopathic medicines are selected on the basis of symptoms, cause, family history and constitution of the person affected. Considering all these factors any of the above (or some other) homeopathic medicine may be indicated and helpful in a case of Multiple Sclerosis.