Disinhibition

Clinic

• It is a lack of restraint manifested in disregard of social conventions, impulsivity, and poor risk assessment.
• Disinhibition affects motor, instinctual, emotional, cognitive, and perceptual aspects with signs and symptoms similar to the diagnostic criteria for mania
• Hypersexuality, hyperphagia, and aggressive outbursts are indicative of disinhibited instinctual drives.

Signs / Symptoms

It is an entity with these signs and symptoms

• Impulsivity
• Disregard for others and social norms
• Aggressive outbursts
• Misconduct and oppositional behaviours
• Disinhibited instinctual drives including risk taking behaviours and hypersexuality.

Causes

• Disinhibition is a common symptom following brain injury, or lesions, particularly to the frontal lobe and primarily to the orbitofrontal cortex.
• The neuropsychiatric sequelae following brain injuries could include diffuse cognitive impairment, with more prominent deficits in the rate of information processing, attention, memory, cognitive flexibility, and problem solving.
• Prominent impulsivity, affective instability, and disinhibition are seen frequently, secondary to injury to frontal, temporal, and limbic areas. In association with the typical cognitive deficits, these sequelae characterise the frequently noted "personality changes" in TBI (Traumatic Brain Injury) patients.
• Disinhibition syndromes, in brain Injuries/ Tumors / Strokes / Epilepsy

Related entities

• It range from mildly inappropriate social behaviour, lack of control over one's behaviour to the full-blown mania
• Several studies in brain traumas and insults have demonstrated significant associations between disinhibition syndromes and visuospatial functions, somatosensation, and spatial memory, motoric, instinctive, affective, and intellectual behaviours.

Entity

Behavioral changes would be the best synonym in viral miasms.

Related Diseases

It have also been reported with

• Mania-like manifestations in old age with lesions to the orbito-frontal and basotemporal cortex involving limbic and frontal connections (orbitofrontal circuit), especially in the right hemisphere.
• Alcohol consumption
• CNS depressants drugs, e.g., benzodiazepines that disinhibit the frontal cortex from self-regulation and control.
• ADHD, hyperactive/impulsive subtype
• Conduct disorder
• Anti-social personality disorder
• Substance abuse