Disinhibition

It is a lack of restraint manifested in disregard of social conventions, impulsivity, and poor risk assessment.
Disinhibition affects motor, instinctual, emotional, cognitive, and perceptual aspects with signs and symptoms similar to the diagnostic criteria for mania
Hypersexuality, hyperphagia, and aggressive outbursts are indicative of disinhibited instinctual drives.
It range from mildly inappropriate social behavior, lack of control over one's behavior to the full-blown mania
Behavioral changes would be its best synonym in viral miasms.

It is an entity with these signs and symptoms

Impulsivity
personality changes: Disregard for others and social norms
Aggressive outbursts
Misconduct and oppositional behaviors
Disinhibited instinctual drives including risk taking behaviors and hypersexuality.
Diffuse cognitive impairment, with more prominent deficits in the rate of Information processing, Attention, memory, Cognitive flexibility, and Problem solving.

TBI (Traumatic Brain Injury) or lesions, particularly to the frontal lobe and primarily to the orbitofrontal cortex.
The neuropsychiatric sequelae following brain injuries could include
Tumors / Strokes / Epilepsy

Cognitive impairments such as
- Visuospatial functions
- Somatosensation
- Spatial memory
Impaired motoric, instinctive, affective, and intellectual behaviors.

Mania-like manifestations in old age with lesions to the orbito-frontal and basotemporal cortex involving limbic and frontal connections (orbitofrontal circuit), especially in the right hemisphere.
ADHD, hyperactive/impulsive subtype
Conduct disorder
Anti-social personality disorder
Substance abuse / Alcohol consumption
CNS depressants drugs, e.g., benzodiazepines that disinhibit the frontal cortex from self-regulation and control.

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