Major depressive disorder

Clinic

• MDD also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities
• In severe cases, depressed people may have psychotic symptoms including delusions or, less commonly, hallucinations, usually unpleasant.
• Older depressed people may have cognitive symptoms of recent onset, such as forgetfulness, and a more noticeable slowing of movements.
• Depressed children may often display an irritable rather than a depressed mood

Symptoms / Signs

Mental

• Low mood: Thoughts and feelings of worthlessness, Inappropriate guilt or regret, Helplessness or Hopelessness.
• Poor concentration and memory
• Withdrawal from social situations and activities
• Reduced sex drive
• Irritability
• Thoughts of Death / Suicide
• Insomnia is common; in the typical pattern, a person wakes very early and cannot get back to sleep.
• Hypersomnia

Physical

• Fatigue
• Headaches
• Digestive problems
• Decreased Appetite resulting in weight loss, although increased appetite and weight gain occasionally occur.

Secondary depression

Depression can also come secondary in

• HIV/AIDS
• Asthma
• Parkinson's disease

Current theories

• Monoaminergic systems
• Circadian rhythm
• Immunological dysfunction
• HPA-axis dysfunction and structural or functional abnormalities
• Emotional circuits

Subtypes

Melancholic depression

• Anhedonia
• A failure of reactivity to pleasurable stimuli
• Exaggerated grief or loss
• Morning agg
• Early-morning waking
• Psychomotor retardation
• Excessive weight loss
• Excessive guilt

Atypical depression

• Mood reactivity (paradoxical anhedonia) and positivity
• Significant weight gain or increased appetite
• Hypersomnia
• Sensation of heaviness in limbs known as leaden paralysis
• Significant long-term social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

• Catatonic depression
  • Disturbances of motor behavior and other symptoms
  • Mute and almost stuporous, and either remains immobile or exhibits purposeless or even bizarre movements.

Depression with anxious distress

Co-occurrence between depression or mania and anxiety, as well as the risk of suicide of depressed individuals with anxiety. Specifying in such a way can also help with the prognosis of those diagnosed with a depressive or bipolar disorder.

Depression with peri-partum onset

Intense, sustained and sometimes disabling depression experienced by women after giving birth or while a woman is pregnant.

Seasonal affective disorder (SAD)

Depressive episodes come on in the autumn or winter, and resolve in spring. The diagnosis is made if at least two episodes have occurred in colder months with none at other times, over a two-year period or longer.

MDD general Entities/ Miasms

Here we have some general / Un-sepecific entities such as

1. Memory weakness
2. Fatigue
3. Concentration impaired
4. Cognition impaired
5. Sleeplessness
6. Sleepiness
7. Weight loss
8. Anorexia
9. Depression
10. Weakness

Considering these 10 entities, we would have 8 miasms including

1. HSV-1
2. HSV-2
3. PLV
4. RBOL
5. B19
6. EBV
7. CMV
8. HBV

Now it 's time to import some special entities.

• Adrenal insufficiency: CMV, HSV-1, HSV-2, EBV
• Constipation: HSV-1, HSV-2, EBV, RBOL
• Ileus / IBS: PLV, CMV, EBV
• Painful, Central sensitization, Fibromyalgia: HSV-1
• Interstitial cystitis: (Urging, Frequency): HSV-1, HSV-2
• Impotence: HSV-1, HSV-2

As you see, RBOL, B19 and HBV do not cover these specific Sigh / Symptoms of this COD, therefore I prefer to omit them. Then we have 5 miams.

PLV

CMV

EBV

HSV-1, 2

Note

This strategy could explain most forms of MDD, except Catatonic MDD. This form of MDD have Bradykinesia, Cathatonia

Miasmatic subtypes

Central

• Brain disorders esp Apathy is the causation
• Main specific entities are: Dementia, Psychosis, Bradi (Kinesia, Phrenia)
• They are slow, mutism and have neurocognitive sign / Symptoms
• Main miasms are GSS, JE, NVCJD

Peripheral

Immunologic / Endocrinologic causes such as adrenal insufficiency, Chronic Fatigue syndrome, IBS etc

Main miasms are EBV, CMV, VZV

Fatigue MDD: EBV, CMV

They are Irritable / Fatigue and have endocrinological Sign / Symptoms

Miasms

EBV: The first and best candidates

It is more useful in peripheral MDD, because of its covering on HPA-axis, CFS, IBS,

GSS: It is more useful in Central MDD because of its coverage on Psychosis, Dementia, Bradikinesia

CMV: It is the second candidate for MDD, because of its covering on HPA-axis, CFS, IBS.

Cluster of disease

Like other cluster of disease, CFS, MDD, Fibromylgia and Celiac disease form a cluster, which I name CMFC cluster. The entities of CMFC cluster are

CMFC cluster entities

Fatigue
Depression
Sleeplessness
Cognition impaired
Concentration impaired

Remedies

1 Alum

Slowness, Paralyzed depression in elderly oeople