Pure Autonomic Failure

Clinic

• PAF is a neurodegenerative disorder of the autonomic nervous system clinically characterized by orthostatic hypotension.
• It has also been known as Bradbury-Eggleston syndrome
• Patients typically present in midlife or later with orthostatic hypotension or syncope.
• Autonomic failure may also manifest as genitourinary, bowel, and thermoregulatory dysfunction. With widespread involvement, patients may present to a variety of different specialties and require multidisciplinary treatment approaches.
• Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein.
• PAF may progress into other synucleinopathies with CNS involvement

Miasm

Same as Neurogenic Syncope