Transmissible Spongiform encephalopathy: Difference between revisions
Jump to navigation
Jump to search
(→Clinic) Tags: Replaced Visual edit |
No edit summary |
||
| Line 3: | Line 3: | ||
* TSEs are a group of progressive and fatal conditions that are associated with prions (CJD, NVCJD, GSS, [[FFI, Fatal Familial Insomnia|FFI]] and [[KRU, Kuru|KRU]]) | * TSEs are a group of progressive and fatal conditions that are associated with prions (CJD, NVCJD, GSS, [[FFI, Fatal Familial Insomnia|FFI]] and [[KRU, Kuru|KRU]]) | ||
* Its name comes from many tiny holes appearing in the cortex in autopsy. | * Its name comes from many tiny holes appearing in the cortex in autopsy. | ||
* Sign / Symptoms | * It is characterized by | ||
**Progressive [[Cerebellar ataxia miasms|cerebellar ataxia]] (Dysarthria, Incoordination) | |||
**Loss of control over muscle movements | |||
=== Sign / Symptoms === | |||
* Dementia: Memory changes, Confusion | |||
* Personality changes | |||
* Problems with movement: Myoclonus | |||
* Depression | |||
* Ataxia: Lack of coordination, Unsteady gait | |||
* Unusual sensations, | |||
* Insomnia, | |||
=== Features === | === Features === | ||
Latest revision as of 14:05, 25 March 2023
Clinic
- TSEs are a group of progressive and fatal conditions that are associated with prions (CJD, NVCJD, GSS, FFI and KRU)
- Its name comes from many tiny holes appearing in the cortex in autopsy.
- It is characterized by
- Progressive cerebellar ataxia (Dysarthria, Incoordination)
- Loss of control over muscle movements
Sign / Symptoms
- Dementia: Memory changes, Confusion
- Personality changes
- Problems with movement: Myoclonus
- Depression
- Ataxia: Lack of coordination, Unsteady gait
- Unusual sensations,
- Insomnia,
Features
- Spongiform change
- Neuronal loss
- Astrocytosis
- Amyloid plaque formation