Bronchiectasis: Difference between revisions

Revision as of 14:52, 2 May 2023

An initial injury to the lung such as from infection, auto-immune destruction of lung tissue
Other destruction of lung tissue as seen in GERD or aspiration syndromes

This leads to impaired mucociliary clearance, obstruction, or a defect in host defense. This triggers a host immune response from neutrophils (elastases), reactive oxygen species, and inflammatory cytokines that results in progressive destruction of normal lung architecture.
In particular, the elastic fibers of bronchi are affected.
The result is permanent abnormal dilation and destruction of the major bronchi and bronchiole walls

MTB

SIL

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+=== Clinic ===
+* It is permanent enlargement of parts of the airways
+* The development of bronchiectasis requires two factors:
+# An initial injury to the lung such as from infection, auto-immune destruction of lung tissue
+# Other destruction of lung tissue as seen in GERD or aspiration syndromes
+* This leads to impaired mucociliary clearance, obstruction, or a defect in host defense. This triggers a host immune response from neutrophils (elastases), reactive oxygen species, and inflammatory cytokines that results in progressive destruction of normal lung architecture.
+* In particular, the elastic fibers of bronchi are affected.
+* The result is permanent abnormal dilation and destruction of the major bronchi and bronchiole walls
+=== Signs and symptoms ===
+* Productive cough (Green or yellow sputum)
+* Dyspnea
+* Wheezing
+* Chest pain
+* Hemoptysis.
+* Expiratory rhonchi
+* Nail clubbing is a rare symptom.
+=== Causes ===
+==== Lung infections ====
+MTB
+==== Autoimmune diseases ====
+* Rheumatoid arthritis
+* Sjögren syndrome
+* Ulcerative colitis and Crohn's disease
+* Allergic bronchopulmonary aspergillosis
 === [[Tissue Salt Remedies]] ===
 SIL