Endotheliopathy miams: Difference between revisions
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=== | === Physiology === | ||
* The endothelium, the cell layer lining | * The endothelium, the cell layer lining blood vessels is not a passive conduit, but can rather be thought of as an organ that interacts with both blood components as well as vascular smooth muscle | ||
* In this role, the endothelium is crucial | * In this role, the endothelium is crucial for regulation and modulation of immune responses, coagulation, and vascular smooth muscle tone | ||
* Endothelial cells release factors such as | * Endothelial cells release factors such as Nitric oxide, Endothelins, prostacyclin, and Von Willebrand factor (vWF) | ||
* Endothelial cell characteristics and | * Endothelial cell characteristics and functions vary by organ (and sometimes within the same organ) | ||
* The pathophysiological understanding of [[atherosclerosis]] has gone through several stages. Today, it is understood as an Inflammatory/ Proliferative disease. | |||
* Endothelial dysfunction plays a central role in the formation of atherosclerotic plaque, in its progression, and in complications. | |||
=== Pathophysiology === | |||
* [[HUS, Hemolytic Uremic Syndrome|Hemolytic Uremic Syndrome]] (HUS) | * [[HUS, Hemolytic Uremic Syndrome|Hemolytic Uremic Syndrome]] (HUS) | ||
* [[TTP, Thrombotic Thrombocytopenic Purpura|Thrombotic Thrombocytopenic Purpura]] (TTP) | * [[TTP, Thrombotic Thrombocytopenic Purpura|Thrombotic Thrombocytopenic Purpura]] (TTP) | ||
* [[DIC, Disemminated Intravsacular Coagulation miasms|Disemminated Intravsacular Coagulation]] (DIC) | * [[DIC, Disemminated Intravsacular Coagulation miasms|Disemminated Intravsacular Coagulation]] (DIC) | ||
* [[Thrombocytopenia miasms|Thrombocytopenia]] Associated Multiple Organ Failure (TAMOF) | * [[Thrombocytopenia miasms|Thrombocytopenia]] Associated Multiple Organ Failure (TAMOF) | ||
* [[Sepsis miasms|Sepsis]] | * [[Sepsis miasms|Sepsis]] | ||
Latest revision as of 21:40, 9 May 2023
Physiology
- The endothelium, the cell layer lining blood vessels is not a passive conduit, but can rather be thought of as an organ that interacts with both blood components as well as vascular smooth muscle
- In this role, the endothelium is crucial for regulation and modulation of immune responses, coagulation, and vascular smooth muscle tone
- Endothelial cells release factors such as Nitric oxide, Endothelins, prostacyclin, and Von Willebrand factor (vWF)
- Endothelial cell characteristics and functions vary by organ (and sometimes within the same organ)
- The pathophysiological understanding of atherosclerosis has gone through several stages. Today, it is understood as an Inflammatory/ Proliferative disease.
- Endothelial dysfunction plays a central role in the formation of atherosclerotic plaque, in its progression, and in complications.
Pathophysiology
- Hemolytic Uremic Syndrome (HUS)
- Thrombotic Thrombocytopenic Purpura (TTP)
- Disemminated Intravsacular Coagulation (DIC)
- Thrombocytopenia Associated Multiple Organ Failure (TAMOF)
- Sepsis