Acute panautonomic neuropathy

Clinic

• Also called Pandysautonomia, is a rare form of Guillain-Barré syndrome
• It is characterized by parasympathetic and sympathetic failure with minimal or no somatosensory or motor impairment.
• Immune-mediated mechanism usually affect efferent postganglionic sympathetic and parasympathetic pathways.
• Slow, incomplete recovery
• Persistent orthostatic hypotension is common
• No effective therapy is available yet.

Sign / Symptoms

• Gastrointestinal symptoms (Abdominal pain, Vomiting, Constipation, Diarrhea, Gastroparesis, Ileus)
• Orthostatic hypotension
• Erectile dysfunction
• Urinary frequency, urgency or retention
• Vasomotor instability (Also referred to as hot Flashing)
• Acrocyanosis
• Reduced salivation, lacrimation and sweating

Entities

HTLV-1