KRU, Kuru: Difference between revisions

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Clinic
=== Clinic ===
 
* Kuru is the first human [[Transmissible Spongiform encephalopathy|transmissible spongiform encephalopathy]] (TSE) or [[prion]] [[Miasm list|miasm]] identified
* It is a prion miasm
* It is a uniformly fatal [[Cerebellum|cerebellar]] ataxic syndrome, usually followed by choreiform and athetoid movements.
Ref: J Neuropathol Exp Neurol. Author manuscript; available in PMC 2016 Nov 23. J Neuropathol Exp Neurol. 2012 Feb; 71(2): 92–103.
* Its important regions are Mind and CNS.
* Its important regions are Mind and CNS.
* '''Kuru''' is a very rare, incurable and fatal neurodegenerative disorder that was formerly common among the Fore people of Papua New Guinea.  
* KRU is a very rare, incurable and fatal neurodegenerative disorder that was formerly common among the Fore people of Papua New Guinea.
* KRU is a form of [[Transmissible Spongiform encephalopathy|transmissible spongiform encephalopathy]] (TSE) which leads to tremors and Incoordination.
* KRU is a form of (TSE) which leads to tremors and Incoordination.
* '''Body tremors''' is a classic symptom of the disease (Titubation (Nodding movement of the head or body)
* '''Body tremors''' is a classic symptom of the disease (Titubation /Nodding movement of the head or body)
* It is also known as the "laughing sickness" due to the '''pathologic bursts of laughter''' which are a symptom of the disease.
* It is also known as the "laughing sickness" due to the '''pathologic bursts of laughter'''  
* Kuru, a transmissible '''spongiform encephalopathy''', is a disease of the nervous system that causes physiological and neurological effects which ultimately lead to death.
 
=== TSE ===
It is characterized by
 
* Progressive cerebellar ataxia (Dysarthria
* Incoordination
* Loss of control over muscle movements
 
 
 
·     
 
Mind
 
 
Psychosis: Behavioral change
 
Ataxia: Tremor, Incoordination
 
Cerebellar Ataxia:
 
Headache.
 


Pneumonia.
=== Three stages ===


# First stage
#* Unsteady stance and gait
#* Decreased muscle control
#* Dysarthria
#* Tremors
# Second stage
#* Incapable of walking without support and experiences
#* Ataxia
#* Severe tremors
#* Emotional instability / Uncontrolled and sporadic laughter
#* Depression
#* [[Tendon reflexes]] are still intact at this stage of the disease.
# Third stage
#* Ataxia progress to the point where it is no longer possible to sit up without support
#* Dysphagia
#* Inability to speak
#* Unresponsive to their surroundings despite maintaining consciousness
#* Chronic ulcerated wounds that can be easily infected
#* Pneumonia or other secondary infections.


Generality: Arthralgia, Weakness, Muscular Weakness
=== Entities ===


* Psychosis: Behavioral change
* [[Cerebellar ataxia miasms|Cerebellar Ataxia]]/ Ataxia: Tremor, Incoordination, Dysarthria, Dysphagia, Gait abnormality
* Pneumonia
* Generality: Arthralgia, Weakness, Headache
* Sensory loss
* Choraoathetosis
* Cranial nerve Palsies / Deficits
* [[LMN, Lower motor neuron entities|LMN]]: Myoclonic Jerking + [[Fasciculation miasms|Fasciculation]] + Muscular Weakness
* Mutism, Apathy, Depression
* Emotional instability
* Hypotonia




Sensory loss. .


Choraoathetosis. Cranial nerve Palsies / Deficits


=== Related Disease ===


* [[Dementia]]
* [[Transmissible Spongiform encephalopathy]]


[[LMN, Lower motor neuron entities|LMN]]: Myoclonic Jerking + [[Fasciculation miasms|Fasciculation]] + Muscular Weakness
=== Remedies ===


=== Disease ===
# AGAR
[[Dementia]]
# Zinc, Cupr, Stram, Phos, Bell, Merc, Plb, Caust
# Nux-m, Sec, Sil, Sul, Ars

Latest revision as of 13:22, 26 March 2023

Clinic

Ref: J Neuropathol Exp Neurol. Author manuscript; available in PMC 2016 Nov 23. J Neuropathol Exp Neurol. 2012 Feb; 71(2): 92–103.

  • Its important regions are Mind and CNS.
  • KRU is a very rare, incurable and fatal neurodegenerative disorder that was formerly common among the Fore people of Papua New Guinea.
  • KRU is a form of (TSE) which leads to tremors and Incoordination.
  • Body tremors is a classic symptom of the disease (Titubation /Nodding movement of the head or body)
  • It is also known as the "laughing sickness" due to the pathologic bursts of laughter

Three stages

  1. First stage
    • Unsteady stance and gait
    • Decreased muscle control
    • Dysarthria
    • Tremors
  2. Second stage
    • Incapable of walking without support and experiences
    • Ataxia
    • Severe tremors
    • Emotional instability / Uncontrolled and sporadic laughter
    • Depression
    • Tendon reflexes are still intact at this stage of the disease.
  3. Third stage
    • Ataxia progress to the point where it is no longer possible to sit up without support
    • Dysphagia
    • Inability to speak
    • Unresponsive to their surroundings despite maintaining consciousness
    • Chronic ulcerated wounds that can be easily infected
    • Pneumonia or other secondary infections.

Entities

  • Psychosis: Behavioral change
  • Cerebellar Ataxia/ Ataxia: Tremor, Incoordination, Dysarthria, Dysphagia, Gait abnormality
  • Pneumonia
  • Generality: Arthralgia, Weakness, Headache
  • Sensory loss
  • Choraoathetosis
  • Cranial nerve Palsies / Deficits
  • LMN: Myoclonic Jerking + Fasciculation + Muscular Weakness
  • Mutism, Apathy, Depression
  • Emotional instability
  • Hypotonia



Related Disease

Remedies

  1. AGAR
  2. Zinc, Cupr, Stram, Phos, Bell, Merc, Plb, Caust
  3. Nux-m, Sec, Sil, Sul, Ars
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