Endotheliopathy miams

Endotheliopathy

• The endothelium, the cell layer lining blood vessels is not a passive conduit, but can rather be thought of as an organ that interacts with both blood components as well as vascular smooth muscle

• In this role, the endothelium is crucial for regulation and modulation of immune responses, coagulation, and vascular smooth muscle tone

• Endothelial cells release factors such as NO, endothelins, prostacyclin, and von Willebrand factor (vWF)

• Endothelial cell characteristics and functions vary by organ (and sometimes within the same organ)

Pathophysiology

• Hemolytic Uremic Syndrome (HUS)
• Thrombotic Thrombocytopenic Purpura (TTP)
• Disemminated Intravsacular Coagulation (DIC)
• Thrombocytopenia Associated Multiple Organ Failure (TAMOF)
• Sepsis [i]

[i] http://www.learnpicu.com/endotheliopathy