Frontotemporal lobar degeneration
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Clinic
- FTLD is a pathological process that occurs in frontotemporal dementia. It is characterized by atrophy in the frontal lobe and temporal lobe of the brain, with sparing of the parietal and occipital lobes.
- Common proteinopathies that are found in FTLD include the accumulation of tau proteins and TAR DNA-binding protein 43 (TDP-43)
Subtypes
Three clinical subtypes of FTLD are
- Frontotemporal dementia which mainly affects a frontomedian network discussed in the context of social cognition.
- Semantic dementia which mainly related to the inferior temporal poles and amygdalae; brain regions that have been discussed in the context of conceptual knowledge, semantic information processing, and social cognition
- Progressive nonfluent aphasia which affects the whole left frontotemporal network for phonological and syntactical processing.