Insulin Autoimmune Syndrome

Clinic

• Insulin autoimmune syndrome is a rare condition that causes hypoglycemia.
• This occurs because the body begins to make a specific kind of protein called antibodies to attack insulin.
• IAS also named Hirata’s disease, is a rare condition characterized by hypoglycemic episodes due to the presence of high titers of insulin autoantibodies (IAA).
• IAS is a form of immune-mediated hypoglycemia, which develops when a triggering factor (ie, a medication or a viral infection) acts on an underlying predisposing genetic background.
• Secondly, IAS can be classified according to the association with other autoimmune diseases
• IAS can be associated with other autoimmune diseases, being included in type 3A or in type 4 autoimmune polyendocrine syndrome
• IAS and Graves’ disease that was originally identified⁹ has been subsequently clarified:^11,29 these two different autoimmune diseases may be associated not as independent manifestations of a common autoimmune condition, but because IAS may be the consequence of the exposure to antithyroid drugs administered to the patient for the cure of the hyperthyroidism.

Causes

• MMP
• RBL,
• CXB
• INFL,
• HCV,
• VZV
• RBOL