Pseudobulbar affect
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Clinic
- PBA is a Mind entity
- PBA is a condition that's characterized by episodes of sudden uncontrollable and inappropriate laughing or crying.
- It typically occurs in people with certain neurological conditions or injuries, which might affect the way the brain controls emotion.
- The primary sign is frequent, involuntary and uncontrollable outbursts of crying or laughing that are exaggerated or not connected to your emotional state.
- Laughter often turns to tears. Your mood will appear normal between episodes, which can occur at any time
Other names
- Emotional lability
- Pathological laughing and crying
- Involuntary emotional expression disorder
- Compulsive laughing or weeping
- Emotional incontinence
Related disease
- Acute disseminated encephalomyelitis [1]
- Alzheimer's dementia
- Parkinson's disease
- Up to 50% of people with ALS
- Up to 48% of people with traumatic brain injury.
- Up to 46% of people with MS
Pathphysiology
- PBA is manifesting as sudden, stereotyped affective outbursts that are not reflective of internal emotion.
- It appears to result from a disruption of the cortico-limbic-subcortical-thalamic-pontocerebellar network involved in emotional expression and regulation with resulting disruptions of neurotransmitter systems.
- It is characterized by stereotyped, involuntary outbursts of affect or objective emotional expressions, that are excessive or incongruent with the individual’s subjective emotional experience or mood.
Miasms
- ↑ Li Z, Luo S, Ou J, Huang R, Wang Y. Persistent pseudobulbar affect secondary to acute disseminated encephalomyelitis. Socioaffect Neurosci Psychol. 2015 Mar 18;5:26210. doi: 10.3402/snp.v5.26210. PMID: 25792370; PMCID: PMC4366481.