Anti LGI1 encephalitis
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Clinic
- They have limbic encephalitis with amnesia and/or confusion (100%)
- Up to 13% of patients with LGI1 Abs develop cognitive impairment. [1]
- Seizures (84-92%): Tonic seizures with movements of Leg, Arm or Face (Faciobrachial dystonic seizures) [2]
- Hyponatremia (60%)
- Movement disorders (Myoclonus/ Dyskinesia)
- Sleep disorders (Hypersomnia, insomnia, REM sleep behavior disorder, sleep reversal)
- Ataxia
- ↑ Ariño H, Armangué T, Petit-Pedrol M, Sabater L, Martinez-Hernandez E, Hara M, Lancaster E, Saiz A, Dalmau J, Graus F. Anti-LGI1-associated cognitive impairment: Presentation and long-term outcome. Neurology. 2016 Aug 23;87(8):759-65. doi: 10.1212/WNL.0000000000003009. Epub 2016 Jul 27. PMID: 27466467; PMCID: PMC4999321.
- ↑ Aurangzeb S, Symmonds M, Knight RK, Kennett R, Wehner T, Irani SR. LGI1-antibody encephalitis is characterised by frequent, multifocal clinical and subclinical seizures. Seizure. 2017 Aug;50:14-17. doi: 10.1016/j.seizure.2017.05.017. Epub 2017 May 30. PMID: 28586706; PMCID: PMC5558811.