Autoimmune oophoritis
Jump to navigation
Jump to search
Clinic
- It is a rare autoimmune disease where the body's own immune system attacks the ovaries.
- This causes the ovaries to have inflammation, atrophy, and fibrosis.
Signs / symptoms
- Autoimmune oophoritis can present with a wide variety of symptoms. It begins with the main symptom, which is amenorrhea
- Other symptoms are related to ovarian cysts, and more common ones are also listed below. A variation of symptoms can occur together, however, that depends on the person and the severity of the disease.
- Primary amenorrhea
- Secondary amenorrhea
- Infertility
- Cramping
- Bloating
- Nausea
- Vomiting
- Sex hormone deficiency
- Hot flushes
- Lower abdominal pain
- Fever
- Malaise
- Vaginal discharge
- Symptoms associated with other coexisting autoimmune conditions
Related disease
Genetics
As Autoimmune oophoritis often occurs in the setting of autoimmune polyendocrine syndromes (APS), mutations in AIRE or HLA-DR3/4 can contribute to its pathology.
Mechanism/ Pathophysiology
There is no set mechanism specifically for autoimmune oophoritis, but it is known that microscopic examinations reveal a picture of inflammatory infiltrate. Selectively attacking the developing follicles and corpus luteum with sparing of the primordial follicles.