Autonomic Dysregulation

Dysautonomia

• Dysautonomia is an umbrella which contains different entities depending on which part of ANS is affected
• Clinical Types are
  • Afferent Baroreflex Failure
  • Familial Dysautonomia
  • Hereditary sensory and autonomic neuropathies (HSAN)
  • Holmes-Adie syndrome (HAS)
  • Autonomic neuropathy

Causes

Dynamic
Sympathetic nervous system	Paraympathetic nervous system	Visceral / Sensory neurons	Enteric nervous system
POTS GAD Pure Autonomic Failure = Neurogenic syncope Neurocardiogenic syncope (NCS)	Vasovagal Syncope		IBS Gastroparesis / GERD

Related diseases

Disease	Pathology	Entities	Miasms
POTS	General Sympathetic Hyperactivity	Hypotention (Orthostatic) Tachicardia Disorientation	RBS
Vasovagal Syncope	General Parasympathetic Hyperactivity	Hypotention Coma Dizziness	SAHF
IBS-C	Local Symp/ Parasympathetic Dysregulations	Ileus Constipation	EBV
IBS-D	Local Symp / Parasympathetic Dysregulations	Ileus Gastroenteritis / Diarrhea	CMV
IBS-M	Local Symp / Parasympathetic Dysregulations	Ileus Constipation	EBV
Gasteroparesis / GERD	Local symp / Parasympathetic Dysregulations	Gastric Dilation	PLV
GAD		Anxiety Anhydrosis
Pure Autonomic Failure = Neurogenic syncope Neurocardiogenic syncope (NCS)

My research

I determine Syncope and Anxiety as entities for Autonomic dysfunction

	General Sympathetic Hyperactivity	General Parasympathetic Hyperactivity	Local symp / Parasympathetic dysregulations
	Anxiety	Depression	Constipation
	Anhydrosis	Dizziness / Brain fog	Dysphagia
	Insomnia	Exercise intolerance / Weakness	Bowel incontinence
	Tachycardia	Syncope/ Orthostatic hypotension	Urinary incontinence or
	Tunnel vision	Vertigo	Urinary retention
		Blurry or double vision
Miasms	RBS	HSV-1, CMV

Other related disease

• HIV/AIDS
• Alcoholism
• Amyloidosis
• Autoimmune disease such as
  • Sjögren's syndrome
  • SLE
  • Autoimmune autonomic ganglionopathy
• Craniocervical instability
• Diabetes
• Eaton-Lambert syndrome
• Ehlers-Danlos syndrome
• Guillain-Barré syndrome
• Long COVID
• Multiple sclerosis
• Paraneoplastic syndrome
• Spinal cord injury or traumatic brain injury
• Synucleinopathy, a group of neurodegenerative diseases including dementia with Lewy bodies, multiple system atrophy, and Parkinson's disease
• Surgery or injury involving the nerves
• Toxicity (vincristine)
• Parkinson’s disease
• Fibromyalgia
• Chronic fatigue syndrome
• Irritable bowel syndrome
• Interstitial cystitis
• Multiple system atrophy (MSA)

Causes

• Inherited or degenerative neurologic diseases (primary dysautonomia)
• Injury of the autonomic nervous system from an acquired disorder (secondary dysautonomia).

Anxiety vs autonomic dysfunction

Anxiety can sometimes physically manifest symptoms resembling autonomic dysfunction. A thorough investigation ruling out physiological causes is crucial, but in cases where relevant tests are performed and no causes are found or symptoms do not match any known disorders, a primary anxiety disorder is possible, but should not be presumed. For such patients, the anxiety sensitivity index may have better predictivity for anxiety disorders, while the Beck anxiety inventory may misleadingly suggest anxiety for patients with dysautonomia.

Entity / Miasm Anxiety

Syncope

Impotence

Incontinence

Gastroparesis

GERD

Achalasia

Thermoregulatory disorder