GSS, Gerstmann Straussler Scheinker syndrome: Difference between revisions
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=== Initial symptoms === | === Initial symptoms === | ||
* Paralysis: '', [[Paraplegia]] / [[Paraparesis]]'' | * Paralysis: '', [[Paraplegia]] / [[Paraparesis]]'' | ||
* Visual disturbances/ Blindness | * Visual disturbances/ Blindness | ||
* '''Seizures''' | * '''Seizures''' | ||
* Movements disorders such as Jerking, '''Myoclonus''' | * Movements disorders such as Jerking, '''Myoclonus''' | ||
| Line 42: | Line 42: | ||
* Progressive [[Ataxia]] / Incoordination may present as unsteadiness, difficulty '''walking''', and '''clumsiness''' /Awkwardness | * Progressive [[Ataxia]] / Incoordination may present as unsteadiness, difficulty '''walking''', and '''clumsiness''' /Awkwardness | ||
* '''Ocular dysmetria: Difficulties judging distance or scale''' | * '''Ocular dysmetria: Difficulties judging distance or scale''' | ||
* Slurred speech which progress to severe Spastic [[Dysarthria]] with [[ | * Slurred speech which progress to severe Spastic [[Dysarthria]] with [[Upper Motot Neuron|UMN]] origin | ||
=== [[Pyramidalism|Pyramidal signs]] / [[ | === [[Pyramidalism|Pyramidal signs]] / [[Upper Motot Neuron|UMN]] === | ||
==== [[Corticospinal tract]] ==== | ==== [[Corticospinal tract]] ==== | ||
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# | # | ||
# | # | ||
#[[Phos, Phosphorus|Phos]], [[Agar, Agaricus Muscarius|Agar]], [[Caust, Causticum|Caust]], [[Lach, Lachesis Mutus|Lach]], [[Con, Conium Maculatum|Con]] | #[[Phos, Phosphorus|Phos]], [[Agar, Agaricus Muscarius|Agar]], [[Caust, Causticum|Caust]], [[Lach, Lachesis Mutus|Lach]], [[Con, Conium Maculatum|Con]] | ||
# Plb, Arg-n, Cocc, Calc, Sul, Stram , Nux-v | # Plb, Arg-n, Cocc, Calc, Sul, Stram , Nux-v | ||
Revision as of 04:47, 3 April 2023
Clinic
- It is a prion miasm
- Typicaly includes progressive Cerebellar ataxia + Pyramidal tract signs + Pseudobulbar paralysis + myoclonus, + Absent tendon reflexes. [1] + Dysesthesia
Parkinsonism
- Tremor
- Spasticity: Rigid muscle tone and progressive muscle stiffness and weakness, causing abnormal, writhing movements
- Bradykinesia: abnormal slowness of movement [2]
- Myoclonus
Initial symptoms
- Paralysis: , Paraplegia / Paraparesis
- Visual disturbances/ Blindness
- Seizures
- Movements disorders such as Jerking, Myoclonus
- Deafness: Less commonly, hearing loss or deafness will develop
Athetosis
- Slow, writhing, involuntary movements
Depression
- Hypomimia or Masked faces: Reduced degree of facial expression / Emotion
- bradyphrenia
Dementia
- Cognitive dysfunction leading to bradyphrenia
- Cognition impairment such as problems in thinking, remembering, reasoning, imagining and processing thoughts which leads to Dementia[3]
- In my research, GSS is the best remedy of Alzheimer disease, because of Memory weakness + Psychosis/ Behavioral change + Impaired Concentration + Depression
Cerebellar Ataxia
- Nystagmus
- Progressive Ataxia / Incoordination may present as unsteadiness, difficulty walking, and clumsiness /Awkwardness
- Ocular dysmetria: Difficulties judging distance or scale
- Slurred speech which progress to severe Spastic Dysarthria with UMN origin
Pyramidal signs / UMN
Corticospinal tract
Corticobulbar tract
- Paralysis of certain cranial nerves
- Pseudobulbar paralysis
- Dysphagia
- Dysarthria / Speech difficult
- Emotional lability / Pseudobulbar affect
- Hyper Reflexia
- Spasm
Remedies
- ↑ Zhao MM, Feng LS, Hou S, Shen PP, Cui L, Feng JC. Gerstmann-Sträussler-Scheinker disease: A case report. World J Clin Cases. 2019 Feb 6;7(3):389-395. doi: 10.12998/wjcc.v7.i3.389. PMID: 30746381; PMCID: PMC6369391.
- ↑ NORD
- ↑ NORD Gratefully acknowledges Pawel P. Liberski, MD, PhD, Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland, for assistance in the preparation of this report.