Hashimoto thyroiditis: Difference between revisions

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* Also known as Autoimmune thyroiditis and chronic lymphocytic thyroiditis
* Also known as Autoimmune thyroiditis and chronic lymphocytic thyroiditis
* It is a chronic disease occurring in the thyroid, most commonly presents as hypothyroidism with or without a goiter including, but not limited to
* Thyroid-stimulating hormone (TSH) concentration is elevated+ Free T4 levels is usually low + positive TPO antibodies
** A larger goiter,
 
** Weight gain
 
** Cold intolerance
=== Sign / Symptoms ===
** Fatigue
* Large goiter
** Myxedema
* Weight gain
** Constipation
* Cold intolerance
** Menstrual disturbances
* Fatigue
** Pale or dry skin
* Myxedema
** Dry, brittle hair
* Constipation
** Depression
* Menstrual disturbances
** Ataxia
* Pale or dry skin
** Muscle weakness
* Dry, brittle hair
* Depression
* Ataxia
* Muscle weakness




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* Graves disease
* Graves disease
* Addison disease
* [[Addison's disease|Addison disease]]
* [[Type 1 DM|Type 1 diabetes]]
* [[Type 1 DM|Type 1 diabetes]]
* [[Sjogren's syndrome]]
* [[Sjogren's syndrome]]
* [[Celiac disease]]
* [[Celiac disease]]
*  
* [[Autoimmune Polyendocrine Syndrome|Autoimmune polyendocrine syndromes type 1 and 2]].
* Autoimmune polyendocrine syndromes type 1 and 2.
 
 
=== Mechanism ===
The two antibodies most commonly implicated in autoimmune thyroiditis are
 
# Antibodies against thyroid peroxidase (TPOAb)
# Thyroglobulin (TgAb).
 
 
=== Laboratory values ===
The initial diagnostic evaluation will start with plasma thyroid-stimulating hormone (TSH) concentration. If elevated, it signifies hypothyroidism. The elevation is usually a marked increase over the normal range and is generally greater than 20 mg/dl. Free T4 levels will usually be lowered, but sometimes might be normal.
 
Doctors may check thyroglobulin antibodies (TgAb) whenever a thyroglobulin test is performed to see if the antibody is interfering. TgAb may also be ordered in regular intervals after a person has been diagnosed with thyroid cancer, and just like TPOAb, it can be associated with Hashimoto's thyroiditis. The most common complement of lab values in patients with autoimmune thyroiditis are high TSH, low T4, and positive TPO antibodies.


=== Related entities ===
=== Related entities ===

Latest revision as of 08:30, 2 May 2023

Clinic

  • Also known as Autoimmune thyroiditis and chronic lymphocytic thyroiditis
  • Thyroid-stimulating hormone (TSH) concentration is elevated+ Free T4 levels is usually low + positive TPO antibodies


Sign / Symptoms

  • Large goiter
  • Weight gain
  • Cold intolerance
  • Fatigue
  • Myxedema
  • Constipation
  • Menstrual disturbances
  • Pale or dry skin
  • Dry, brittle hair
  • Depression
  • Ataxia
  • Muscle weakness


Related disease

Related entities

Vitiligo


Miasms

HCV

MMP

EBV

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